血尿酸水平 IL-2 IL-6和TNF-α水平与抑郁症患者抑郁症状及躯体化症状评分的相关性分析

doi:10.3969/j.issn.1006-6233.2021.10.013

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Abstract Objective: To study the correlation of the levels of blood uric acid, interleukin-2(IL -2), IL-6, tumour necrosis factor-α(TNF-α) and inflammatory factors with scores of depressive symptoms and somatization symptom in patients with depression. Methods: This retrospective study included 177 patients with depression (study group) diagnosed and treated in the hospital between February 2018 and October 2020. Meanwhile, 153 healthy volunteers were selected as the control group. The levels of blood uric acid, interleukin-2 (IL-2), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the two groups were detected. The Hamilton Depression Scale (HAMD) was used to assess psychological states of the two groups. The correlation between the levels of blood uric acid and inflammatory factors and the scores of depressive symptoms and somatization symptom in patients with depression was analyzed. Results: The levels of serum IL-2, IL-6 and TNF-α in the study group were significantly higher than those in the control group, and the blood uric acid levels were significantly lower than those in the control group (P<0.05). The HAMD scores of the study group were significantly higher than those of the control group (P<0.05). The serum uric acid levels of patients with severe symptoms were significantly higher than those of patients with mild and moderate symptoms, while the levels of serum IL-2, IL-6 and TNF-α were significantly higher than those of patients with mild and moderate symptoms (P<0.05). Serum uric acid level was negatively correlated with the severity of depressive symptoms, while the levels of serum IL-2, IL-6 and TNF-α were positively correlated with the severity of depressive symptoms (P<0.05). Serum uric acid level was negatively correlated with the scores of anxiety/somatization and circadian changes (P<0.05), and there was no significant correlation with other factors (P>0.05). Serum IL-2, IL-6 and TNF-α levels were positively correlated with the scores of anxiety/somatization and circadian changes (P<0.05), but there was no significant correlation with other factors (P>0.05). Conclusion: The blood uric acid level is decreased, and inflammatory factor levels are elevated in patients with depression. The severity of depressive symptoms and somatization symptom scores are negatively correlated with blood uric acid level, and positively correlated with IL-2, IL6 and TNF-α levels.

Key words： Blood uric acid Interleukin-2 Depression Hamilton depression scale Tumour necrosis factor-α

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	MENG Yun
	LI Bo

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MENG Yun,LI Bo. The Correlation Between the Levels of Blood Uric Acid IL-2 IL-6 and TNF-α and Scores of Depressive Symptoms and Somatization Symptom in Patients with Depression[J]. HeBei Med, 2021, 27(10): 1647-1651.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.10.013 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I10/1647

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