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| Effect of Compound Anisodine Hydrobromide Injection on VEGF and IGF-1 in Patients with Non Proliferative Diabetic Retinopathy |
| WANG Fenfen, MA Weiguo, YIN Xiaohong, et al |
| The First Affiliated Hospital of Xi'an Medical College, Shaanxi Xi'an 710077, China |
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Abstract Objective: To investigate the therapeutic effect of compound anisodine on non-proliferative diabetic retinopathy, and to provide reference for its application. Methods: According to simple random sampling and manual stratification, 146 patients with non-proliferative diabetic retinopathy admitted to the First Affiliated Hospital of Xi'an Medical College from September 2018 to September 2020 were divided into 2 groups, with 73 cases in each group. The control group was treated with total retinal laser photocoagulation (PRP)+ conventional treatment, and the observation group was treated with compound camphorine, comparison before and after treatment clinical signs (hemorrhage, edema disappeared and effusion absorption time), fundus index [vision, bleeding area, seepage area, number of micro hemangioma, within the scope of 30 o view the average sensitivity threshold (MS), retinal oscillation potential total amplitude values (oPs)], vascular endothelial growth factor (VEGF) and insulin-like growth factor number one (IGF 1) level change and clinical curative effect. Results: After treatment, the total effective rate of observation group (95.89%) was higher than that of control group (75.34%)(χ2=18.048, P=0.000). The bleeding absorption time, edema disappearance time and exudation absorption time in the observation group were significantly shorter than those in the control group, while the bleeding area and exudation area were also smaller than those in the control group (P<0.05). In terms of the difference before and after treatment, the increase in visual acuity, MS, and oPs total wave amplitude difference in the observation group was significantly greater than that in the control group (P<0.05), and the reduction of microangioma was significantly greater than that in the control group (P<0.05). The observation group had significantly greater reductions in VEGF and IGF-1 than the control group (P<0.05). Conclusion: Compound anisodine can effectively improve the clinical symptoms of patients with non-proliferative diabetic retinopathy, regulate the levels of vascular endothelial growth factor and insulin-like growth factor 1, and promote ocular microcirculation.
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2021, Vol. 27 
