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| The Effect of Interferon α-2b on the Treatment of Respiratory Syncytial Virus Bronchiolitis in Children and Its Effect on Serum SP-D TGF-β and IL-4 Levels |
| LIU Dan,YANG Xiangui,GAO Xiaohong |
| Anshan Central Hospital, Liaoning Anshan 114000, China |
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Abstract Objective: To analyze the effect of interferon α-2b on pediatric respiratory syncytial virus bronchiolitis and its effect on serum SP-D、TGF-β and IL-4 levels.Methods: 120 children with respiratory syncytial virus bronchiolitis admitted to our hospital (from January 2017 to October 2019) were selected and divided into group A (using conventional treatment methods) and group B (on the basis of the control group, interferon α-2b treatment method was used), 60 cases in each group; then 60 cases of healthy children were selected as the control group. The clinical symptoms and the disappearance time of basic vital signs (fever, wheezing, lung rales and cough, etc.) after treatment, and the total effective rate of clinical treatment were compared. The serum SP-D, TGF-β and IL-4 of the three groups were analyzed.Results: The disappearance time of fever, wheezing, lung rales and cough in group B was significantly shorter than that in group A, and the difference was statistically significant (P<0.05); the total clinical effective rate of group B was significantly higher than that in group A, and the difference was statistically significant (P<0.05).The results of single factor ANOVA variance analysis showed that the serum SP-D、TGF-β and IL-4 levels of the three groups were statistically significant (P<0.05). The results showed that the serum SP-D and IL-4 levels of bronchiolitis in group A and group B were significantly higher than those in the control group, and the serum TGF-β levels were significantly lower than those in the control group (P<0.05).The SP-D level of group B was significantly higher than that of the control group, lower than that of group A, the TGF-β level was significantly lower than that of the control group, and the IL-4 level was significantly higher than that of the control group (P<0.05).Conclusion: The effect of interferon α-2b on pediatric respiratory syncytial virus bronchiolitis is remarkable, at the same time, it can significantly reduce the serum SP-D、IL-4 level and improve the TGF-β level of children.
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2021, Vol. 27 
