|
|
Comparative Study of Two Methods of Sedation and Analgesia in Rescue Tracheal Intubation |
MO Liujun, GUO Hao, YANG Liping, et al |
Wuzhou People's Hospital, Guangxi Wuzhou 543000, China |
|
|
Abstract Objective: To study the efficacy and safety of sufentanil combined with midazolam to induce sedation and analgesia to substitute fentanyl combined with midazolam. Methods: A total of 80 patients admitted to the Department of Intensive Medicine of our hospital for tracheal intubation due to various reasons were selected from January 1, 2019 to June 30, 2020. The grouping method was simple random grouping, and they were divided into sufentanil group and fentanyl group (40 cases in each). Sufentanil group used sufentanil 0.25-0.5μg / kg + midazolam 0.025-0.05mg / kg before intravenous intubation; Fentanyl group used before intubation Tani 0.5-1μg / kg + midazolam 0.025~0.05mg / kg; 4-5min after administration of the drug, tracheal intubation was conducted immediately. The blood pressure, heart rate, oxygen saturation, and respiratory rate of the two groups of patients were recorded before intubation, during intubation, and after intubation; at the same time, the reverse inhalation, apnea, arrhythmia, and intubation success during intubation were monitored. The required number of times, the success rate of one-time intubation, the incidence of choking cough during the induction period of general anesthesia and the serious situation were monitored. Results: In the fentanyl group and the sufentanil group, the differences in the mean arterial pressure, respiratory rate, blood oxygen saturation, and heart rate were statistically significant (all P<0.001), the patient's basic data, before and after intubation data showed statistically significant difference (all P<0.001), and there were interactions between different groups and time, the differences between the two groups at the same time point were statistically significant (all P<0.001). The same group at different time points within the period, the mean arterial pressure and blood oxygen saturation gradually increased, and the respiratory rate and heart rate gradually decreased (all P<0.001). Sufentanil group had lower incidence of reflux aspiration, apnea, and arrhythmia than fentanyl group (P <0.05). Sufentanil group required less successful intubation than the fentntanyl group (P <0.05). The degree of choking in sufentanil group was better than that in the fentanyl group (P <0.05).Conclusion: Sufentanil combined with midazolam is safer and more reliable than fentanyl combined with midazolam.
|
|
|
|
|
[1] 卢航,刘美仪.我院儿科住院麻醉药品用药分析[J].广东药科大学学报,2020,36(2):274~276. [2] 苗蕾.罗哌卡因复合舒芬太尼用于剖宫产麻醉的临床效果[J].河南医学研究,2020,29(10):1802~1803. [3] 邹志进,韩晓华.右美托咪定复合舒芬太尼镇痛联合腹横肌平面阻滞对经腹全子宫全切术患者早期康复的影响[J].中国医学创新,2020,17(10):61~64. [4] 王冬梅,董新春.浅析右美托咪啶与舒芬太尼预防七氟醚麻醉术后躁动的作用[J].中国医药指南,2020,18(9):52. [5] 岳伟,王伟.罗哌卡因复合舒芬太尼硬膜外麻醉与腰硬联合阻滞麻醉用于无痛分娩的临床分析[J].中国现代药物应用,2020,14(6):154~156. [6] 陈俊峰,李艳,赵宁,邵新学.氟比洛芬酯联合髂筋膜间隙阻滞对全髋关节置换术后炎症反应及疼痛的影响[J].国际骨科学杂志,2020,41(2):108~113. [7] 崔志卿,石海霞,吴凡.右美托咪定联合舒芬太尼用于老年胸外科手术患者术后镇痛的疗效观察[J].中国医药,2020,15(4):542~544. |
|
|
|