大剂量牛肺泡表面活性物质治疗新生儿呼吸窘迫征的医学价值和经济价值研究

doi:10.3969/j.issn.1006-6233.2020.09.039

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Abstract Objective: To investigate the clinical and economic values of high dose bovine alveolar surfactant (PS) in the treatment of neonatal respiratory distress syndrome (NRDS).Methods: 90 cases of NRDS diagnosed and treated in the Department of Pediatrics of our hospital from February 2017 to August 2019 were prospectively selected and divided into the routine group and the study group with the simple random number table method, 45 cases in each group.All NRDS patients were treated with CPAP, expectoration and anti infection.70 mg / kg standard dose and 100 mg / kg high dose PS were injected into tracheal intubation in routine group and study group respectively.The changes of blood gas analysis indexes (PaO₂, PaO₂, pH) and ventilator parameters (PEEP, FiO₂, RI) were observed before and 48 hours after treatment, and the CPAP time, PS medication times, complication rate, mortality, length of hospital stay and total medical expenses were recorded.Results: Values of PaO₂, pH and PEEP were significantly increased and PaCO₂, FiO₂ and RI were significantly decreased in the two groups 48 hours after treatment, and the difference was statistically significant (P<0.05).Values of PaO₂, pH, PEEP, PaCO₂, FiO₂ and RI of the study group were significantly higher than those of the control group.The difference was statistically significant (P<0.05).The complication rate and mortality rate of NRDS in the study group were 8.89% and 2.22% respectively, which were slightly lower than those in the control group (13.33% and 4.44%).There was no significant difference (P>0.05).The time of CPAP and the times of PS administration in the study group were lower than those in the control group (P<0.05).The length of stay and the total cost of medical treatment in the study group were less than those in the routine group, and the difference was statistically significant (P<0.05).Compared with the standard dose of 70 mg / kg PS in the treatment of NRDS, the high dose of 100 mg / kg PS can save about 7200 yuan / case of medical expenses, and the total savings of 45 NRDS patients in the study group are about 324000 yuan.Conclusion: Compared with the standard dose of 70 mg / kg PS in the treatment of NRDS, the effect of high dose of 100 mg / kg PS is better, with significant clinical and economic values.

Key words： Neonatal respiratory distress syndrome Bovine alveolar surfactant Clinical efficacy Complications Economic value

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	CHEN Kun
	QIN Huajun

Cite this article:

CHEN Kun,QIN Huajun. Study on the Medical and Economic Values of High Dose Bovine Alveolar Surfactant in the Treatment of Neonatal Respiratory Distress Syndrome[J]. HeBei Med, 2020, 26(9): 1573-1577.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.09.039 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I9/1573