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The Correlation Between CD8+/FOXP3+ Ratio PD-L1 Expression in Tissues and Prognosis in Patients Undergoing Radical Operation of Esophageal Squamous Carcinoma |
ZHANG Chengwei, CHANG Kuan, MAO Zhigang, et al |
Air Force Hospital, Northern Theater Command of the Chinese People's Liberation Army, Liaoning Shenyang 110042, China |
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Abstract Objective: To explore the correlation between CD8+/FOXP3+, expression of programmed death ligand 1 (PD-L1) in tissues and prognosis of patients undergoing radical operation of esophageal squamous carcinoma (ESCC).Methods: During the period from January 2014 to January 2019, 110 archived wax specimens and 110 wax specimens of normal tissues adjacent to the cancer (longer than 5 cm away from lesion, confirmed as cancer-free infiltration) from patients who underwent radical operation of ESCC in the hospital were enrolled as study objects.The expression of CD8+, FOXP3+ and PD-L1 in ESCC tissues was detected by immunohistochemistry, and the relationship between pathological parameters and prognosis was analyzed.Results: The positive expression rate of CD8+/FOXP3+ in ESCC tissues was lower than that in adjacent tissues, while the positive expression rate of PD-L1 was higher than adjacent tissues (P<0.05).Univariate and multivariate analysis showed that TNM stage T3, lymph node metastasis, positive expression of PD-L1 and negative expression of CD8+/FOXP3+ were independent risk factors affecting prognosis of ESCC patients (P<0.05).Conclusion: Positive expression of CD8+/FOXP3+, negative expression of PD-L1, TNM stage T3 and lymph node metastasis are independent risk factors affecting prognosis of patients after radical operation of ESCC.
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