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| Effects of Magnesium Sulfate, Nifedipine Tablets Combined with Diazepam on Blood Pressure SEng and SFlt-1 and Pregnancy Outcomes in Patients with Severe Preeclampsia |
| WANG Hong, YANG Wen, ZHOU Yan, et al |
| Wuhan Children's Hospital Wuhan Maternal and Child Health Hospital / Tongji Medical College at Huazhong University of Science and Technology, Hubei Wuhan 430016, China |
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Abstract Objective: To explore the effects of magnesium sulfate, nifedipine tablets (Nf) combined with diazepam on blood pressure, serum soluble endoglin (sEng) and soluble vascular endothelial growth factor receptor 1 (sFlt-1) and pregnancy outcomes in patients with severe preeclampsia (S-PE). Methods: A total of 160 S-PE patients admitted to our hospital from June 2018 to June 2019 were selected for study. They were divided into control group and study group in a 1: 1 ratio according to the simple random number table method, with 80 cases in each group. Patients in control group were treated with magnesium sulfate + Nf while patients in study group were additionally given diazepam on the basis of control group. The clinical efficacy after 1 week of treatment and 24h blood pressure [systolic blood pressure (SBP), diastolic blood pressure (DBP)] and serum indicators (sEng, sFlt-1) before treatment and 1 week after treatment were compared between the two groups, and the pregnancy outcomes and occurrence of adverse drug reactions during treatment were recorded. Results: 1 week after treatment, the total effective rate in study group was significantly higher than that in control group(92.50% vs 81.25%) (P<0.05). The levels of 24h SBP and 24h DBP, serum sEng and sFlt-1 in the two groups were significantly decreased compared with those before treatment, and the above indicators in study group were significantly different from those in control group at the same period (P<0.05). The pregnancy outcome follow-up revealed that in study group it was better than in control group (P<0.05). The adverse drug reaction rate in study group was significantly lower than that in control group during treatment (P<0.05). Conclusion: For patients with severe preeclampsia, the application of magnesium sulfate, nifedipine tablets combined with diazepam can effectively improve the blood pressure, alleviate vascular endothelial damage and promote pregnancy outcomes, and it has higher safety and better application value.
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2020, Vol. 26 
