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| An analysis of the Clinical Value of Plasma miR-92a and miR-93 in the Diagnosis and Short-term Prognosis of Acute ST Segment Elevation Myocardial Infarction |
| XIU Mingwen, BIAN Yuyao |
| Hebei Petrochina Central Hospital, Hebei Langfang 065000, China |
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Abstract Objective: To investigate the clinical value of plasma miR-92a and miR-93 in the diagnosis and short-term prognosis of acute ST segment elevation myocardial infarction. Methods: 160 patients with acute ST segment elevation myocardial infarction confirmed by emergence department of our hospital were selected into case group, 152 healthy adults were selected into control group. The plasma levels of miR-92a and miR-93 were measured in the two groups. ROC curve was used to evaluate the diagnostic value of plasma miR-92a and miR-93 in patients with acute ST segment elevation myocardial infarction. The incidence of major cardiovascular events (MACE) in patients with acute ST segment elevation myocardial infarction was observed after 3 months follow-up. Logistic regression analysis was used to explore the influencing factors of MACE in patients with acute ST segment elevation myocardial infarction. Results: Compared with the control group, the plasma level of miR-92a was significantly decreased at 4h, 8h, 12h, 24h, and 48h in the case group, while the level of miR-93 increased(P<0.05). At 72h and 1 week after the onset, there were no significant changes in miR-92a and miR-93 levels between the case group and the control group(P>0.05). MiR-92a was positively correlated with HDL-C, and miR-93 was positively correlated with TG, LDL-C, hs-CRP, NT-proBNP; miR-92a was negatively correlated with TG, LDL-C, hs-CRP, NT-proBNP, and miR-93 was negatively correlated with HDL-C(P<0.05). The AUC, sensitivity, specificity, accuracy and cutoff of miR-93 were 0.851, 76.3%, 79.6%, 82.6%, and 2.35, respectively. The AUC, sensitivity, specificity, accuracy and cutoff of miR-92a were 0.846, 75.9%, 72.6%, 81.1%, and 3.59, respectively. The incidence of MACE in the miR-92a high-expression group was higher than that of the miR-92a low-expression group, and the incidence in the miR-93 high-expression group was lower than that of miR-93 low expression group(P<0.05). Logistic regression analysis showed that high-level miR-93 and low-level miR-92a were risk factors for MACE in patients with acute ST-segment elevation myocardial infarction (OR=4.62, 5.02, P<0.05). Conclusion: The level of miR-92a in patients with acute ST segment elevation myocardial infarction is lower, and miR-93 is higher. MiR-92a and miR-93 are expected to be biomarkers for the diagnosis of acute ST segment elevation myocardial infarction. High level miR-93 and low level miR-92a are risk factors for poor prognosis in patients with acute ST segment elevation myocardial infarction.
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2020, Vol. 26 
