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| The Effects and Safety of Different Treatments on Serum β-hCG P and VEGF in Patients with Ectopic Pregnancy |
| LI Fan, WANG Ruping, ZHOU Ping |
| The First People's Hospital of First Affiliated Huainan Anhui University of Science and Technology, Anhui Huainan 232007, China |
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Abstract Objective: To explore the effects of conservative medication, open surgery and laparoscopic surgery on patients with ectopic pregnancy. Methods: The clinical data of 80 patients with ectopic pregnancy admitted to the hospital from March 2016 to March 2019 were retrospectively analyzed. According to different treatment methods, they were divided into conservative medication group (mifepristone + methotrexate + Shapei prescription, 30 cases), open group (openfallopian tube resection, 30 cases) and laparoscopic group (laparoscopic fallopian tube resection, 20 cases). At 1 week after treatment, the levels of serum β-human chorionic gonadotropin (β-hCG), progesterone (P) and vascular endothelial growth factor (VEGF) were compared among the three groups, and the clinical efficacy was evaluated by serum indexes and imaging results. The adverse reactions or complications were monitored in the three groups after treatment. The hospital stay and hospitalization expense were compared among the three groups. At 3 months after treatment, the psychological states of the patients were evaluated by Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS), and the sexual function was evaluated by Female Sexual Function Index (FSFI). Results: At 1 week after treatment, the levels of serum β-hCG, P and VEGF in open group and laparoscopic group were significantly lower than those in conservative medication group (P<0.05), but there were no significant differences between open group and laparoscopic group (P>0.05). The efficacy was 100.00% in open group and laparoscopic group, which was significantly higher than that in conservative medication group with 63.33% (P<0.05). There were no significant differences in the incidence rates of adverse reactions or complications among the three groups (P>0.05). The hospital stay in conservative medication group was significantly longer than that in open group and laparoscopic group (P<0.05), and the hospitalization expense was significantly lower than that in open group and laparoscopic group (P<0.05). At 3 months after treatment, the reductions of SAS and SDS scores in conservative medication group were greater than those in open group (P<0.05) while the decrease of FSFI score was smaller than that in open group (P<0.05), but there were no significant differences compared with those in laparoscopic group (P>0.05). Conclusion: Surgical treatment of patients with ectopic pregnancy can improve serum β-hCG, P and VEGF faster, and its early efficacy is better than conservative treatment, but conservative treatment is superior to surgical treatment in hospitalization expense and psychological states and sexual function status after treatment. And surgical treatment medication have better safety, and it is necessary to take individualized treatment by combining with the actual situation in clinical practice.
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2020, Vol. 26 
