肝脏瞬时弹性超声成像对CHB合并酒精性肝病患者肝纤维化分期的诊断价值分析

doi:10.3969/j.issn.1006-6233.2020.06.017

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Abstract Objective: To analyze the diagnostic value of liver transient elastography in the staging of liver fibrosis in patients with chronic hepatitis B (CHB) and alcoholic liver disease. Methods: A retrospective study was carried out to collect the clinical data of 67 patients with CHB and alcoholic liver disease in our hospital. All patients were examined by transient elastic ultrasound and liver biopsy. According to Ishak score, liver fibrosis was periodized. The differences of baseline data, blood biochemical indexes and liver hardness values of patients with different stages of liver fibrosis were compared. Through Spearman correlation analysis, the relationship between the liver hardness and the stage of liver fibrosis was analyzed. The receiver operating characteristic (ROC) curve of the subjects was plotted to evaluate the predictive value of liver hardness on liver fibrosis, and the sensitivity and specificity were calculated. Results: Of the 67 patients, there were 8 cases in stage 0, 15 cases in stage 1, 17 cases in stage 2, 9 cases in stage 3, 8 cases in stage 4, 7 cases in stage 5 and 3 cases in stage 6. The differences of ages, albumin, total bilirubin, alanine aminotransferase (ALT) and prothrombin activity (PTA) in different stages of liver fibrosis were statistically significant (P<0.05); the differences of gender, body mass index and aspartate aminotransferase (AST) in different stages of liver fibrosis were not statistically significant (P>0.05). There was a significant difference in the hardness of liver between the patients with different stages of fibrosis (P<0.001). The Spearman correlation analysis showed that there was a positive correlation between liver hardness and fibrosis stage (P<0.001). When the threshold value of liver hardness was 7.75 kPa, the sensitivity and specificity of liver fibrosis were 89.83% and 75.00%, respectively, and the area under ROC curve was 0.84 (P<0.001). Conclusion:Transient elastic ultrasound imaging of liver has a high diagnostic value for the degree of liver fibrosis in CHB patients with alcoholic liver disease, which is applicable in evaluating the stage of liver fibrosis in early stage.

Key words： Transient elastic ultrasound imaging of liver Alcoholic liver disease Chronic hepatitis B Liver fibrosis

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	LIU Pinlan
	JIANG Linlin

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LIU Pinlan,JIANG Linlin. An Analysis of the Diagnostic Value of Transient Elastography in the Staging of Liver Fibrosis in CHB Patients with Alcoholic Liver Disease[J]. HeBei Med, 2020, 26(6): 959-962.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.06.017 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I6/959

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