HOTAIR EZH2和VEGF在鼻咽癌组织中的表达情况及其对预后的影响

doi:10.3969/j.issn.1006-6233.2020.05.014

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Abstract Objective: To analyze the expression of vascular endothelial growth factor (VEGF), enhancer of zeste homolog 2 (EZH2) and long-chain noncoding RNA Hox transcript antisense RNA (HOTAIR) in nasopharyngeal carcinoma and its effect on prognosis. Methods: The clinical data of 72 patients with nasopharyngeal carcinoma (NPC group) and 54 patients with chronic inflammation of nasopharynx (control group) were collected by retrospective study. The expression of VEGF and EZH2 were detected by immunohistochemistry, and the expression of VEGF, EZH2 and HOTAIR mRNA were detected by real-time fluorescence quantitative polymerase chain reaction. According to the expression of hotair in nasopharyngeal carcinoma, nasopharyngeal carcinoma patients were divided into low expression group and high expression group. Results: The expression of VEGF and EZH2 in nasopharyngeal carcinoma group was significantly higher than that in control group (P<0.001). Compared with the control group, the relative expression of VEGF, EZH2 and HOTAIR mRNA in nasopharyngeal carcinoma group was significantly increased (P<0.05). There were significant differences in pathological grade, N stage, M stage, short-term efficacy between the high-expression group and the low-expression group (P<0.05); there were no significant differences in age, gender, pathological type between the two groups (P>0.05). Conclusion: VEGF, EZH2 and HOTAIR are highly expressed in nasopharyngeal carcinoma, and hotair may play a role in inducing distant metastasis of nasopharyngeal carcinoma through EZH2 and VEGF, which is closely related to poor prognosis.

Key words： Nasopharyngeal carcinoma Vascular endothelial growth factor Enhancer of zeste homolog 2 Hox transcript antisense RNA

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.05.014 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I5/758

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