血浆Ficolin-3水平与肺炎支原体感染患儿疾病分期及病情程度的相关性分析

doi:10.3969/j.issn.1006-6233.2020.04.039

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Abstract Objective: To study the correlation between plasma fibrin gel -3 (Ficolin-3) level and disease stages, severity of children with Mycoplasma pneumoniae (MP) infection. Methods: 78 children with MP infection admitted to the Department of Pediatrics from June 2018 to June 2019 were selected as the study objects, and 88 children with MP infection were selected as the control group, the expression levels of ficolin-3 in plasma, interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor (TNF-α) were measured by enzyme-linked immunosorbent assay (ELISA), detection of serum immunoglobulin (IgM, IGA) expression by immunoturbidimetry and the correlations between the expression level of ficolin-3 and disease stage, disease degree, IL-8, IL-10, TNF-α, IgM, IgA were analyzed. Results: Compared with the control group, the levels of ficolin-3, IL-8, TNF-α and IgM in the plasma of MMP group were significantly higher (P<0.05), while the levels of IL-10 and IgA were significantly lower (P<0.05). Compared with the convalescent group, the levels of ficolin-3, IL-8, TNF-α and IgM in the plasma of the acute group were significantly higher (P<0.05), while the levels of IL-10 and IgA decreased significantly (P<0.05). Compared with the mild group, the expression levels of ficolin-3, IL-8, TNF-α and IgM in the severe group were significantly higher (P<0.05), while the expression levels of IL-10 and IgA were significantly lower (P<0.05). The expression level of ficolin-3 in plasma of children with MMP was positively correlated with disease stage, disease severity, the expression levels of IL-8, TNF-α and IgM in serum (P<0.05), and negatively correlated with the expression levels of IL-10 and IgA in serum (P<0.05). Conclusion: The expression level of ficolin-3 in plasma of MMP patients is significantly increased, which is positively correlated with disease stage, disease degree, expression levels of serum IL-8, TNF-α and IgM, and negatively correlated with the expressions of serum IL-10 and IgA, it may be a clinical index to evaluate the condition of children with Mycoplasma pneumoniae pneumonia (MMP).

Key words： Plasma fibrin gel protein -3 Mycoplasma pneumonia Interleukin -8 Interleukin -10 Tumor necrosis factor

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.04.039 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I4/693

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