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| Effects of Different INR on Thromboembolic Events and Major Adverse Cardiovascular Events in Patients with Coronary Heart Disease Complicated with Atrial Fibrillation |
| XU Xianbin, LU Xusheng, CHEN Erzhou, et al |
| Chaozhou Central Hospital, Guangdong Chaozhou521000, Chian |
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Abstract Objective: To study the effect of INR on thromboembolic events and adverse cardiovascular events in patients with coronary heart disease and atrial fibrillation. Methods: From December 2013 to October 2018, 120 patients with coronary heart disease and atrial fibrillation who had thromboembolic events and adverse cardiovascular events were selected as the observation group, and 110 patients with coronary heart disease and atrial fibrillation who did not have thromboembolic events and adverse cardiovascular events were selected as the control group. The risk factors of thromboembolism and adverse cardiovascular events were analyzed by single factor and multi factor Logistic regression, and the distribution of INR value in the observation group was observed; the predictive value of INR for thromboembolism and adverse cardiovascular events in patients with coronary heart disease and atrial fibrillation was analyzed by ROC curve. Results: Univariate and multivariate Logistic regression analysis showed that the age of INR, left atrial enlargement ≥ 40mm, left ventricular ejection fraction < 50%, hypertension and chronic kidney disease cardiac function grade were the influencing factors and independent risk factors of cardiovascular adverse events and thrombus embolism events in patients with coronary heart disease complicated with AF (P<0.05).There were 6 cases (5.00%) with INR value < 1.5, 4 cases (3.33%) with INR value of 1.5-1.99, 20 cases (16.67%) with INR value of 2.0-2.49,90 cases (75.00%) with INR value ≥ 2.5 in the observation group. The sensitivity and specificity of INR in predicting thrombus embolism and adverse cardiovascular events in patients with coronary heart disease complicated with atrial fibrillation were 77.5%, 100.0%, 0.915 and 2.35 respectively. Conclusion: INR in patients with coronary heart disease complicated with atrial fibrillation is an independent risk factor for thrombus embolism and adverse cardiovascular events, which has certain value in predicting thrombus embolism and adverse cardiovascular events. For example, the higher the probability of thrombus embolism and adverse cardiovascular events in patients with coronary heart disease complicated with atrial fibrillation, the higher the probability of thrombus embolism and adverse cardiovascular events.
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2020, Vol. 26 
