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| Effect of Xinmupei on Hemodynamics and Uterine Contraction of Cesarean Women Under Combined Spinal Epidural Anesthesia |
| GUO Rong, LI Jiuhui, LI Shou, et al |
| Xining First People's Hospital, Qinghai Xining 810000, China |
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Abstract Objective: To observe the influence of hemabate on hemodynamics of parturient undergoing cesarean section after administrated by different ways. Methods: 60 patients with high-risk cesarean section underwent combined spinal and epidural anesthesia were randomly divided into Xinmu Peigong injection group (M group) and deltoid injection group (D group), 30 cases in each group. Non-invasive hemodynamic monitoring system were used to investivagate mean artery pressure (MAP), heart rate (HR),stroke volume (SV), cardiac output (CO), total peripheral resistance (SVR) before hemabate administration (baseline) and every 5 minute following hemabate administration. Results: Compared with pre-dose, there was a decrease in TPR, an increase in CO, and an increase in SV (P<0.05) in both groups after injection, MAP decreased in group M after administration for 5 min,in group D after 10 min (P<0.05). The HR of patients in group M increased 5 minutes after administration (P<0.05), and there was no significant change in HR at any time after administration in group D (P>0.05) ; the incidence of palpitations and chest pain in group M higher than group D (P<0.05). The uterine contraction scores of the uterus injection group at 2.5 min and 5 min after treatment were higher than those in the deltoid injection group (P<0.05). The incidence of maternal chest tightness in the deltoid injection group was higher than that in the uterine injection group. (P<0.05). Conclusion: The changes of hemodynamics after injection of hemabate during cesarean section,patients showed high cardiac output and low resistance, and this influence continued for a long time. The injection of myometrium injected had more obvious influence on hemodynamics.
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2020, Vol. 26 
