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| Correlation between Serum Galactose Lectin-3 Level and Cardiac Function and Inflammatory Response in Patients with CHF after MI |
| WAN Rong, XU Feng, ZHANG Xiaoxia, et al |
| Zaozhuang Mining Group Central Hospital of Shandong, Shandong Zaozhuang 277000, China |
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Abstract Objective: To explore the correlation between serum galactose lectin-3 (Gal-3) levels and cardiac function and inflammatory response in patients with chronic heart failure (CHF) after myocardial infarction (MI). Methods: The clinical data of 156 patients with CHF in our hospital in recent years were analyzed retrospectively. According to the history of MI, 78 patients in the observation group and 78 patients in the control group were divided. The results of Gal-3, inflammation index and echocardiography were compared between the two groups, and the correlation between Gal-3 and cardiac function and inflammation was analyzed. Results: The levels of CRP, TNF - α and Gal-3 in the observation group were (5.93 ± 0.82) mg / L, (16.48 ± 1.05) ng / L, (9.82 ± 1.13) ng / mL, respectively, higher than those in the control group (4.89 ± 0.71) mg / L, (12.17 ± 1.12) ng / L, (6.08 ± 1.04) ng / mL (P<0.05). The LVEF of the observation group was (50.08 ± 2.08)%, lower than that of the control group (57.62 ± 2.19)% (P<0.05). According to Pearson analysis, the level of Gal-3 in the observation group was positively correlated with CRP and TNF - α (r = 0.778, 0.725, P<0.01), and negatively correlated with LVEF (r = -0.854, P<0.01). Conclusion: Gal-3 was positively correlated with inflammatory response and negatively correlated with cardiac function in patients with CHF after MI.
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2020, Vol. 26 
