凉血散瘀汤加减联合羟苯磺酸钙治疗糖尿病视网膜病变患者的临床疗效症状积分及VEGF的影响

doi:01.3969/j.issn.1006-6233.2020.12.038

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1243 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To explore the effect of Liangxuesanyu decoction combined with calcium dobesilate in the treatment of patients with diabetic retinopathy on clinical efficacy, symptom score and vascular endothelial growth factor (VEGF). Methods: 152 patients (152 eyes) admitted to our hospital from October 2017 to December 2019 were diagnosed with diabetic retinopathy as the research object, the clinical data of all patients were retrospectively analyzed. According to the different treatment plans, the patients were divided into a control group (75 cases) and a study group (77 cases). The control group was treated with calcium dobesilate, and the research group was supplemented with Liangxuesanyu decoction. During the treatment, the patient's condition was closely observed, and the clinical efficacy, symptom score, and VEGF effect between the two groups were compared. Results: The total clinical effective rate of the control group was significantly lower than that of the study group (88.00% vs 97.40%) (P <0.05). After treatment, the macular thickness, hemorrhagic spots, hemangioma, symptom score, and visual acuity of the two groups significantly improved, and the improvement in the study group was greater than that in the control group (P <0.05). The expressions of TNF-α and VEGF in the two groups significantly reduced, and the reduction in the study group was significantly better than that in the control group (P <0.05). Conclusion: Liangxuesanyu decoction combined with calcium dobesilate in the treatment of diabetic retinopathy has a good clinical effect, which can effectively alleviate the change of the disease and improve the severity of symptoms, and it is worthy of popularization and application in clinic.

Key words： Diabetic retinopathy Liangxue sanyu decoction Calcium dobesilate Symptom score Vascular endothelial growth factor

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	TONG Tian
	ZHANG Cong
	JIANG Xiu
	et al

Cite this article:

TONG Tian,ZHANG Cong,JIANG Xiu, et al. Effects of Liangxuesanyu Decoction Combined with Calcium Dobesilate in the Treatment of Patients with Diabetic Retinopathy on Clinical Efficacy, Symptom Score and VEGF[J]. HeBei Med, 2020, 26(12): 2094-2097.

URL:

http://www.hbyxzzs.cn/EN/01.3969/j.issn.1006-6233.2020.12.038 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I12/2094

[1] 文静,刘毓,高爱民,等.地特胰岛素联合门冬胰岛素治疗儿童1型糖尿病的疗效观察[J].保健医学研究与实践,2018,15(3):55~57.
[2] 杨芳,杨艳蓓,方毅,等.凉血散瘀汤加减对非增殖期糖尿病视网膜病变患者血液流变学及疗效分析[J].糖尿病新世界,2016,19(19):37~38.
[3] 丁文萃,王丽晖,杨洁,等.血糖波动与老年2型糖尿病患者并发认知功能障碍的关系研究[J].解放军医药杂志,2019,30(9):112~114.
[4] 刘凤桐,王晓莉.糖网明目汤联合羟苯磺酸钙片治疗糖尿病性视网膜病变临床研究[J].中医学报,2018,33(7):121~123.
[5] 陈娟,高鹏霞.血清中胰岛素样生长因子Ⅰ、肿瘤坏死因子α、血管内皮生长因子165在糖尿病视网膜病变中的诊断价值[J].中华内分泌代谢杂志,2018,34(11):935~938.
[6] 马京平.复方血栓通胶囊联合羟苯磺酸钙治疗早期糖尿病性视网膜病变[J].国际眼科杂志,2018,18(2):305~308.
[7] 郑博,杨卫华,吴茂念,等.基于眼底照相的糖尿病视网膜病变智能辅助诊断技术评价体系的建立及应用[J].中华实验眼科杂志,2019,37(8):674~679.
[8] 王阜蕾,李春林.激光联合羟苯磺酸钙治疗老年Ⅲ~Ⅳ期糖尿病性视网膜病变对玻璃体PEDF、VEGI表达的影响[J].中国激光医学杂志,2019,27(4):197~202.
[9] Zhu Z T, Ophthalmology D O, Hospital J H. Effect of laser photocoagulation combined with calcium dobesilate for diabetic retinopathy[J]. international eye science, 2017,17(2):525~526.
[10] 高利娟,李月红,李珊,等.复明片联合利拉鲁肽在治疗糖尿病视网膜病变中的应用及对患者IGF-1、VEGF水平影响[J].中国药物应用与监测,2019,16(4):199~203.
[11] 刘爱琴,宋子宣.改良视网膜光凝术治疗糖尿病视网膜病变的效果及其对血清血管内皮生长因子和内皮素1水平的影响[J].新乡医学院学报,2019,36(4):72~75.
[12] 郭朝霞.凉血散瘀汤加味联合羟苯磺酸钙治疗非增殖期糖尿病视网膜病变瘀热阻络证疗效观察[J].实用中医药杂志,2020,36(2):196~197.
[13] 李莉.激光光凝联合羟苯磺酸钙及血栓通对糖尿病视网膜病变微循环及炎性因子的影响[J].应用激光,2019,39(3):57~59.