聚乙二醇干扰素α-2b联合恩替卡韦对慢性乙肝患者RORγt eGFR的影响

doi:10.3969/j.issn.1006-6233.2020.12.036

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Abstract Objective: To study the curative efficacy of pegylated interferon alpha-2b combined with entecavirin in treating chronic hepatitis B and its effects onRetinal acid-related orphan receptor (ROR gamt), glomerular filtration rate (eGFR). Methods: 100 patients of chronic hepatitis B who received therapy from June 2017 - June 2018 were selected as research objects. By lottery, they were divided into observation group (n=52) and control group (n=48). The control group was treated with entecavir, while the observation group was treated with pegylated interferon alpha - 2B, Then efficacy, ROR T, eGFR, T cell subsets, interleukin-17 (IL-17), interleukin-4 (IL-4), interferon -α(INF-α) were compared. Results: The total effective rates of the two groups were 75.00% and 54.17%, respectively, with significant differences (P<0.05). There was no significant difference in ROR T and eGFR between the two groups before treatment. After treatment, the levels of ROR T and eGFR in both groups were improved, and the observation group was better than the control group (P<0.05). After treatment, T cell subsets in both groups were improved, and the improvement in the observation group was more significant than that in the control group (P<0.05). Before treatment, there was no significant difference in serum cytokine levels between the two groups. After treatment, serum cytokine levels in both groups were improved, and the levels of INF- and IL-17 and IL-4 in the observation group were higher than those in the control group (P<0.05). Conclusion: In chronic hepatitis B patients, the application of peg interferon alpha-2b combined with entecavir has a significant effect, which can effectively improve the ROR gamma t and eGFR levels of patients.

Key words： Pegylated interferon alpha-2b Entecavir Chronic hepatitis B Retinoic acid-related orphan receptors Glomerular filtration rate

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.12.036 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I12/2087

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