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| Correlation Analysis of Blood Coagulation Index and Severity in Patients with Craniocerebral Injury |
| WANG Kunpeng, YANG Jie, HU Tiemin, et al |
| The Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China |
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Abstract Objective: To explore the correlation between coagulation index and severity of patients withcraniocerebral injury. Methods: To collectmedical records of 87 patients with craniocerebral injuryfromOctober 2017 to October 2018,useglasgow coma scale to assess the severity of injury,make use ofbivariate regression analysis, multiple linear regression equation andarea under the receiver-operating characteristic curve(ROC) to analyze the correlation between coagulation index and severity. Results: Bivariate regression analysis results showed that GCS was correlated with prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), d-dimer (D-D), albumin (ALB) and glucose (GLU), there were significant difference(P<0.05). By using stepwise fitting,three independent variables were selected intooptimal multiple regression analysis equation, they were D-D, PT and GLU, R=0.836,R2=0.615. The ROC curve analysis results showed that the area under the ROC curve of D-D, PT and GLU predicted the GCS value of patients with craniocerebral injury were respectively0.863, 0.736 and 0.727,indicating that when blood D-D value≥4.58ug/ml, blood PT value≥13.55s and blood GLU value≥8.29mmol/L, the patients was in critical condition. Conclusion: In the early judgment of patients with craniocerebral injury, the change of coagulation index has predictive significance for the patient's injury, which could be combined with the patient's post-injury blood D-D, PT, GLU value to help determine the patient's condition, andthentimely gave corresponding treatment.
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2020, Vol. 26 
