术前血清E-selectin与ICAM-1及MMP-2表达与肺癌手术患者预后的关系

doi:10.3969/j.issn.1006-6233.2020.11.03

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1805 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To explore the correlation between preoperative expressions of serum E-selectin,intercellular adhesion molecule-1 (ICAM-1) and matrix metalloproteinase-2 (MMP-2) and prognosis of patients after lung cancer surgery.Methods: Ninety-five patients with lung cancer treated in our hospital from January 2015 to December 2016 were selected,and 80 healthy people for physical examination at the same period were selected as control group.The levels of serum E-selectin,ICAM-1 and MMP-2 were detected among patients with lung cancer before surgery,at 1 week after surgery and at 1 month after surgery and in control group on the day of physical examination.The patients were followed up for more than 3 years,and the survival status was recorded.Receiver operating characteristic curve (ROC) and area under the curve (AUC) were used to analyze the predictive value of preoperative serum E-selectin,ICAM-1 and MMP-2 on prognosis.Multivariate analysis affecting the prognosis of lung cancer patients was performed by COX proportional hazard regression model.Taking the median value of serum results as the cut-off point,the patients were divided into low expression group (loss than median value,47 cases) and high expression group (more than median value,48 cases),and the survival time was recorded,and Kaplan-Meier survival curve was plotted.Results: The levels of serum E-selectin,ICAM-1 and MMP-2 in lung cancer group before surgery,at 1 week after surgery and at 1 month after surgery showed a decreasing trend (P<0.05),and were higher than those in control group (P<0.05).The levels of preoperative serum E-selectin,ICAM-1 and MMP-2 in death group were higher than those in survival group (P<0.05).The AUC values of preoperative serum E-selectin,ICAM-1 and MMP-2 in predicting 3-year death were 0.869,0.830 and 0.808 respectively,and they were lower than that of combined detection of 0.972 (P<0.05).COX proportional hazard regression analysis results showed that preoperative serum E-selectin,ICAM-1 and MMP-2 were independent factors for prognosis of patients after lung cancer surgery (P<0.05).The 3-year survival rates of preoperative serum E-selectin,ICAM-1 and MMP-2 low expression groups were 21.28%,23.40% and 23.40%,which were higher than those of high expression groups with 10.42%,8.33% and 8.33% (P<0.05).Conclusion: Levels of serum E-selectin,ICAM-1 and MMP-2 in patients with lung cancer before and after surgery are higher than those in healthy people,and the three preoperative indexes are independent factors that affect the prognosis,and have a high predictive value on the 3-year survival of patients,and patients with low expressions of preoperative serum indexes have longer survival time and better prognosis.

Key words： Lung cancer E-selectin Intercellular adhesion molecule-1 Matrix metalloproteinase-2

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.11.03 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I11/1771

[1] 孙可欣,郑荣寿,曾红梅,等.2014年中国肺癌发病和死亡分析[J].中华肿瘤杂志,2018,40(11):805~811.
[2] 陈志营,谭平,宋杨.非小细胞肺癌患者血浆可溶性P、E选择素的表达[J].中国实验诊断学,2018,22(6):1042~1043.
[3] 程建平,赵晓琳,黄坤,等.直肠癌患者血浆纤维蛋白原、D-二聚体及血清可溶性细胞间黏附分子-1的表达水平及临床意义[J].癌症进展,2019,17(15):1800~1802.
[4] 时晓霞,唐德才,尹刚,等.黄芪、莪术配伍对人卵巢癌HO-8910原位移植瘤组织中MMP-2、FGF-2、BCL-2表达的影响[J].中华中医药学刊,2018,36(6):1312~1315,后插8~后插10.
[5] 张用,毕建平,皮国良,等.国际肺癌研究协会第八版国际肺癌TNM分期修订稿解读[J].肿瘤防治研究,2016,43(4):313~318.
[6] 王静,李子超,宋朝君,等.肺癌组织钙网蛋白高表达与患者生存期的相关性分析[J].细胞与分子免疫学杂志,2017,33(12):1676~1680.
[7] 石海蓉,张影,陆颖,等.血清肿瘤标志物在肺癌骨转移诊断中的价值[J].中华核医学与分子影像杂志,2018,38(5):331~335.
[8] LoicRaffray,Claude Giry,Yoga Thirapathi,et al.Increased levels of soluble forms of E-selectin and ICAM-1 adhesion molecules during human leptospirosis[J].Plos One,2017,12(7):e0180474.
[9] Conor Donnelly,Brad Dykstra,NandiniMondal,et al.Optimizing human treg immunotherapy by treg subset selection and E-selectin ligand expression[J].Scientific Reports,2018,8(1):420.
[10] Sheila M,Keating,Jennifer L,et al.The effect of HIV infection and HCV viremia on inflammatory mediators and hepatic injury:the women's interagency HIV study[J].Plos One,2017,12(9):e0181004.
[11] Mahmut Balkan,HalitAkbas,NecmettinPenbegul,et al.Possible lack of association between E469K polymorphism of ICAM-1 and non-obstructive azoospermia in south-east Turkey[J].Biotechnology &Biotechnological Equipment,2017,31(1):143147.
[12] 朱省戒,周玲,陈美琴,等.非小细胞肺癌化疗前后黏附分子及细胞新生指标变化及意义[J].中国卫生检验杂志,2018,28(14):1750~1752,1756.
[13] 杜立平,秦晓玲.非小细胞肺癌患者p53蛋白和MMP2表达水平与同步放化疗的相关性[J].标记免疫分析与临床,2017,24(9):1015~1017,1021.