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| Effect of Xiaoer Chaigui Tuire Granule on Physical Signs and Immune Function in the Treatment of Acute Upper Respiratory Tract Infection |
| ZHAO Xin, HE Yan-yao, TIAN Jing |
| Department of Pharmacy, Hunan Children's Hospital, Hunan Changsha 410011, China |
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Abstract Objective: To investigate the effect of Xiaoer Chaigui Tuire granule on physical signs and immune function in the treatment of acute upper respiratory tract infection. Methods: 228 children with acute upper respiratory tract infection in our hospital from January 2013 to December 2017 were selected, and divided into two groups according to random number method, each with 114 cases. Observation group received Xiaoer Chaigui Tuire granule and ribavirin injection, while control group received routine treatment. Temperature at admission, 24h, 48h and 72h were recorded and compared between groups. Then the clinical efficacy and immune function were analyzed. Results: The total effective rate was significantly higher in observation group than in control group (97.37% vs 84.21%, P<0.05). At 24h, 48h and 72h after admission, body temperature showed a decrease in both groups (P<0.05), and was lower in observation group than in control group (P<0.05). After treatment, there was an increase in CD3+, CD4+ and CD4+/CD8+ levels, and a decrease in CD8+ level in both groups (P<0.05), and observation group had significantly higher CD3+, CD4+ and CD4+/CD8+ levels, and lower CD8+ level than those of control group after treatment (P<0.05). CRP and WBC were decreased in both groups after treatment (P<0.05), and were lower in observation group than in control group (P<0.05). The clinical effect of observation group was positively correlated with immune function indicators CD3+, CD4+, CD8+, and CD4+/CD8+. Conclusion: Application of Xiaoer Chaigui Tuire granule as an adjuvant treatment for children with acute upper respiratory tract infection can effectively enhance the immune function and rapidly reduce the body temperature.
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2020, Vol. 26 
