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| Efficacy of CRRT on Severe Pancreatitis and Its Influence on Pancreatic Microcirculation Indexes and Serum Ghrelin and PCT Levels |
| LIU Yan, CHEN Qin, YUAN Xue, et al |
| The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Sichuan Nanchong 637000, China |
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Abstract Objective: To analyze the efficacy of continuous renal replacement therapy (CRRT) in the treatment of severe pancreatitis and its influence on pancreatic microcirculation indexes and serum Ghrelin and procalcitonin (PCT) levels. Methods: The clinical data of each 102 patients with severe pancreatitis treated by CRRT (observation group) and conventional treatment (control group) were retrospectively analyzed. The times of clinical indexes remission were recorded in the two groups, and pancreatic microcirculation indexes [pancreatic blood flow (BF), blood flow volume (BV)], serological markers [Ghrelin, PCT, thromboxane A2 (TXA2)] and acute physiology and chronic health evaluation (APACHE II), and Balthazar computed tomography (CT) severity index (CTSI) were compared between the two groups before treatment and after 3d of treatment. Results: The recovery time of serum amylase, bowel sounds, abdominal pain remission and abdominal distension remission in observation group were lower than those in control group (P<0.05). After 3d of treatment, the pancreatic microcirculation indexes (pancreatic BF, BV) in the two groups were increased compared with those before treatment (P<0.05), and the indexes in observation group were higher than those in control group (P<0.05). Serological markers (serum Ghrelin, The PCT, TXA2) and scores of APACHE II and CTSI in the two groups were decreased compared with those before treatment (P<0.05), and the markers and scores in observation group were lower than those in control group (P<0.05). Conclusions: CRRT therapy has significant effects in the treatment of severe pancreatitis. And it can not only promote the relief of symptoms, but also relieve the pancreatic microcirculation disorder, and it has positive significance in disease outcomes of patients.
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2020, Vol. 26 
