新辅助化疗和ISR对直肠癌患者肛肠动力学排便功能的影响

doi:10.3969/j.issn.1006-6233.2020.01.015

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Abstract Objective: To explore the effects of neoadjuvant chemotherapy and ISR on anorectal dynamics and defecation in patients with rectal cancer. Methods: 73 rectal cancer patients who underwent ISR in our hospital from January 2015 to November 2016 were selected as the study objects. According to the treatment methods, they were divided into two groups: the control group (35 cases) received conventional ISR, and the observation group (38 cases) received neoadjuvant chemotherapy combined with ISR. The anorectal motility, defecation ability and adverse reactions were compared between the two groups. Results: In the two groups, the changes of hpz, ARP and MSP were significant (P < 0.05) compared with each other at different time points, and the changes of ARP and MSP in the control group were significantly higher than those in the control group at 1 month, 3 months and 6 months after operation (P < 0.05). There was no significant difference between the two groups (P > 0.05). Infection, intestinal obstruction, urinary retention and other events occurred in the 2 groups * but there was no significant difference in the incidence of adverse events between the 2 groups (P>0.05). Conclusion: Neoadjuvant chemotherapy combined with ISR in the treatment of rectal cancer has certain influence on anorectal motility, but it does not increase defecation difficulties and other adverse events.

Key words： Rectal cancer ISR Neoadjuvant chemotherapy Anorectal function

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	LIU Yang
	LI Dapeng
	GAO Fei
	et al

Cite this article:

LIU Yang,LI Dapeng,GAO Fei, et al. Effects of Neoadjuvant Chemotherapy and ISR on Anorectal Dynamics and Defecation in Patients with Rectal Cancer[J]. HeBei Med, 2020, 26(1): 63-66.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.01.015 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I1/63

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