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| Effects of Warfarin on Coagulation Platelet Parameters and Hemorheology in Patients with Atrial Fibrillation |
| BAI Chongyang, ZHANG Huizhong |
| Tangdu Hospital of the Force Military Medical University, Shanxi Xi'an 710000, China |
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Abstract Objective: To investigate the coagulation function, platelet parameters and hemorheology of warfarin in patients with atrial fibrillation. Methods: 94 patients with atrial fibrillation were enrolled from our hospital from October 2016 to October 2018. The patients were simple random divided into two groups, 47 in each group. One group was the control group and treated with aspirin. The other group was the observation group, which was treated with warfarin. The changes of coagulation function, platelet parameters and blood rheology related indexes before and after treatment were compared between the two groups. Results: After treatment, the coagulation function related indicators, partial activated thrombin time (APTT), thrombin time (TT) and prothrombin time (PT) were significantly higher in the observation group than in the control group (P<0.05). Platelet-related indicators in the observation group after treatment, platelet surface membrane glycoprotein IIb/IIIa (GPIIb/IIIa), platelet alpha granule membrane glycoprotein (CD62p), platelet membrane glycoprotein fibrinogen receptor (PAC-1) were significantly lower In the control group (P<0.05). After treatment, the fibrinogen (FIB), low blood viscosity and high blood viscosity of the observation group were significantly lower than those of the control group (P<0.05). The difference between the two groups was statistically significant. Conclusion: Warfarin in patients with atrial fibrillation can effectively improve blood coagulation, platelet and blood rheology, has clinical application value.
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2020, Vol. 26 
