|
|
Study on Effect of Butylphthalide Capsule on Vascular Dementia after Stroke |
LIN Zhecong, HAN Qiaolin, WU Xiyan, et al |
Jieyang People's Hospital, Guangdong Jieyang 522000, China |
|
|
Abstract Objective: To investigate the clinical effect of butylphthalide capsule in the treatment of post-stroke vascular dementia. Methods: 70 patients with vascular dementia hospitalized in our hospital from July 2015 to December 2017 were prospectively selected. They were divided into two groups according to simple random number table, 35 cases in each group. The control group received nimodipine orally for routine treatment.The clinical efficacy and adverse reactions during treatment were observed and compared between the two groups, cognitive function was evaluated by simple mental state scale (MMSE), (CDR) was used to evaluate the curative effect of dementia severity, and activity of daily living scale (ADL) was used to evaluate daily students before and after treatment. The changes of serum MMSE, CDR, ADL level before and after treatment were compared. Results: Compared with the clinical efficacy of the two groups, the total effective rate of the observation group was significantly higher than that of the control group (P< 0.05). The analysis of variance of repeated measurements showed that the interaction of time factor and time factor of MMSE, CDR, ADL score and grouping had statistical significance (P< 0.05). It showed that the differences of MMSE, CDR and ADL score before and after treatment in the observation group was different from those before and after the control group. The difference of MMSE, CDR and ADL score in the observation group was significantly greater than that in the control group before and after the treatment. The analysis of variance of repeated measurements showed that the interaction of time factors and time factors of SOD, MDA and BDNF levels and groups had statistical significance (P< 0.05). It showed that the differences of SOD, MDA and BDNF levels before and after treatment in the observation group were different from those before and after treatment in the control group. The differences of SOD, MDA and BDNF levels in the observation group before and after treatment were significantly greater than those in the control group. There were no serious adverse reactions related to this study. Conclusion: Butylphthalide capsule is effective in the treatment of post-stroke vascular dementia. It can significantly improve the degree of dementia, cognitive function and ability of daily living. No adverse reactions occurred during the treatment. It is safe and effective in clinical treatment, and is worthy of clinical application and promotion.
|
|
|
|
|
[1] D W K Kay,Genetics.Alzheimer's disease and senile dementia[J]. British Journal of Psychiatry, 2018, 154(3):311~320. [2] 马青,唐民科,孙文燕.血管性痴呆中医发病机制现代研究述要[J].中华中医药杂志,2018,33(1):212~215. [3] 郑雄伟,张威,张晓改.老年人缺血性脑卒中后血管性痴呆的危险因素分析[J].心肺血管病杂志,2018,37(3):197~200. [4] 曾晓莉,张文娟,赵博,等.慢性脑缺血神经保护机制及药物研究进展[J].中国脑血管病杂志,2017,14(11):607~611. [5] 韦冬梅.急性心肌梗死患者冠状动脉病变与同型半胱氨酸超氧化物歧化酶水平相关性研究[J].山西医药杂志,2019,48(4):57~59. [6] 刘宗环,胡向军,彭瑞云,等.BDNF和NMDAR在微波辐射对学习记忆影响中作用的研究进展[J].解放军预防医学杂志,2017,35(8):1008~1010. [7] 刘娜,徐明,王华龙,等.红景天对血管性痴呆大鼠认知功能的影响[J].河北医科大学学报,2017,38(6):621~624. [8] 曹冰清,殷董,宋允章,王涛.脑血疏口服液联合多奈哌齐、尼莫地平治疗血管性痴呆的临床疗效[J].中西医结合心脑血管病杂志,2018,16(15):2131~2134. [9] 王建民,周冬亮,覃宏伟,等.丁苯酞对血管性痴呆患者血清中细胞因子、可溶性凋亡因子、抗氧化分子的影响[J].海南医学院学报,2017,23(3):422~424. [10] 蒋颖.丁苯酞软胶囊联合阿托伐他汀钙片治疗血管性痴呆患者的临床效果[J].中国医药导报,2018,15(14):48~52. |
|
|
|