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| Effects of Hemodialysis and High-flux Hemodialysis on Serum PTH and Body Nutritional Status of Patients with Uremia Complicated with Hyperphosphatemia |
| CHANG Wenjing, et al |
| Beijing Century Temple Hospital, Capital Medical University, Beijing 100038, China |
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Abstract Objective: To explore the clinical effects of hemodialysis (HD) and high-flux hemodialysis (HFHD) in the treatment of uremia with hyperphosphatemia. Methods: The clinical data of 126 patients with uremia complicated with hyperphosphatemia were retrospectively analyzed. The patients with HFHD for blood purification therapy were included in observation group (n=74), and the patients with HD were included in control group (n=52). The serotoxin indexes [creatinine (SCr), urea nitrogen (BUN), parathyroid hormone (PTH), β2-microglobulin (β2-MG)], calcium-phosphorus metabolism indicators (blood calcium, blood phosphorus, calcium-phosphorus product) and nutritional status indicators [serum albumin (ALB), serum prealbumin (p-ALB), upper arm muscle circumference (AMC)] were compared between the two groups before treatment and after 3 months of treatment. Results: After 3 months of treatment, the serum levels of SCr and BUN in the two groups were significantly decreased compared with those before treatment while the serum calcium level was significantly increased compared with that before treatment (P<0.05), but there were no statistically significant differences between the groups at the same time (P>0.05). The levels of serum PTH, β2-MG and blood phosphorus and calcium-phosphorus product in the two groups were significantly lower than those before treatment, and the levels in observation group were significantly lower than those in control group at the same time (P<0.05). The levels of ALB, p-ALB and AMC in the two groups were significantly increased compared with those before treatment, and the levels in observation group were significantly higher than those in control group at the same time (P<0.05). Conclusions: Compared with HD, HFHD for patients with uremia and hyperphosphatemia can effectively remove PTH in the body, more actively correct calcium-phosphorus metabolism, improve the body nutritional status, and benefit its prognosis and rehabilitation.
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2019, Vol. 25 
