新生血管性青光眼患者房水和血浆中PlGF IL-1β和TGF-β<sub>2</sub>的测定及意义

doi:10.3969/j.issn.1006-6233.2019.09.027

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Abstract Objective: To detect the levels of placental growth factor (PlGF), interleukin-1β (IL-1β), and transforming growth factor (TGF-β2) in aqueous humor and plasma of patients with neovascular glaucoma (NVG), and to explore the relationships between the levels of PlGF, IL-1β and TGF-β2 in aqueous humor and plasma. Methods:42 patients (42 eyes) diagnosed as NVG in our hospital from April 2016 to September 2018 were selected, 50 cases (50 eyes) of patients with age-related cataract (ARC) were selected as control group, enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of PlGF, IL-1β and TGF-β2 in aqueous humor and serum. Results: The levels of PlGF, IL-1β and TGF-β2 in aqueous humor and serum of patients in group NVG were significantly higher than those of ARC patients (P < 0.05); the levels of PlGF and TGF-β2 in aqueous humor were significantly higher than those in serum in group NVG (P < 0.05); there was no significant change in the levels of PlGF and TGF-β2 between aqueous humor with serum of ARC patients (P>0.05); the level of IL-1β in the two groups was significantly higher than that in the serum (P<0.05). Pearson test showed that the levels of PlGF, IL-1β and TGF-β2 in aqueous humor and serum of NVG patients were positively correlated (P < 0.05). Conclusion: The levels of PlGF, IL-1β and TGF-β2 in aqueous humor and serum of patients in group NVG are significantly higher than those in control group, it may be related to NVG disease.

Key words： Neovascular glaucoma Aqueous humor Plasma Placental growth factor Transforming growth factor β2 Interleukin 1β

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	LIU Xuelian
	WU Guihua
	ZHANG Yan

Cite this article:

LIU Xuelian,WU Guihua,ZHANG Yan. Determinations and Significances of PlGF, IL-1β and TGF-β2 in Aqueous Humor and Plasma of Patients with Neovascular Glaucoma[J]. HeBei Med, 2019, 25(9): 1512-1515.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.09.027 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I9/1512

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