辅酶Q10注射液联合左卡尼汀对老年慢性肺源性心脏病并心功能不全的疗效分析

doi:10.3969/j.issn.1006-6233.2019.09.021

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Abstract Objective: To study the curative efficacy of coenzyme Q10 injection combined with levocarnitine in treatment of senior chronic pulmonary heart disease with cardiac insufficiency. Methods: 86 patients of senior chronic pulmonary heart disease with cardiac insufficiency who received therapy from January 2015 to May 2018 in our hospital were selected as research objects, according to random number table, those patients were divided into the 45 cases of the observation group and 41 cases of the control group, on the basis of routine treatment, the control group was treated with levocarnitine, while the observation group was treated with coenzyme Q10 injection on the basis of the control group, they were treated for 3 weeks. The clinical efficacy, hemorheology, blood gas analysis, cardiac function and adverse reactions were compared between the two groups. Results: After treatment, the total effective rate of the observation group was significantly higher than those in the control group (P＜0.05); The whole blood viscosity, high shear rate, low shear rate, plasma viscosity and whole blood reduced viscosity in the observation group were significantly lower than those in the control group (P＜0.05); the partial pressure of oxygen (PaO₂) in the observation group was significantly higher than those in the control group, and the partial pressure of carbon dioxide (PaCO₂) in the observation group was significantly lower than those in the control group (P＜0.05); the heart rate (HR) and left ventricular end-diastolic diameter (LVEDD) in the observation group were significantly lower than those in the control group, the left ventricular ejection fraction (LVEF) was significantly higher than those in the control group, and the 6-minute walking distance was significantly longer than those in the control group (P＜0.05); there was no significant difference in adverse reactions between the two groups during treatment (P＞0.05). Conclusion: Coenzyme Q10 injection combined with levocarnitine is well for senior chronic pulmonary heart disease with cardiac insufficiency, and has good drug safety

Key words： Chronic pulmonary heart disease Cardiac insufficiency Coenzyme Q10 injection Levocarnitine Hemorheology

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	QIU Rong
	GUO Shen
	GUO Hua
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QIU Rong,GUO Shen,GUO Hua, et al. Exploring the Effect of Coenzyme Q10 Injection Combined with Levocarnitine on Elderly Patients with Chronic Pulmonary Heart Disease and Cardiac Insufficiency[J]. HeBei Med, 2019, 25(9): 1488-1493.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.09.021 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I9/1488

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