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| Effect of Dexmedetomidine on Analgesia and Intestinal Function after Radical Resection of Colon Cancer |
| AN Bin, LIU Shuo, TAO Deqiang |
| Space Center Hospital, Beijing 100049, China |
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Abstract Objective: To study the effect of dexmedetomidine on analgesia and intestinal function after radical resection of colon cancer. Methods: 80 patients with colon cancer underwent radical operation in our hospital from March 2017 to March 2018 were selected. According to simple random number table, the patients were divided into observation group (45 cases) and control group (35 cases). According to simple random number table,those patients were divided into the observation group (n=45) and the control group (n=38). The control group was injected with normal saline before induction of general anesthesia, while the observation group was injected with dexmedetomidine. Then the surgical recovery index (recovery time, first exhaust time, recovery time of spontaneous breathing, time of eating common food, recovery time of bowel sounds), Visual Analogue Scale/Score at 1 hour, 3 hours, 6 hours, 12 hours, 24 hours after operation, Systolic pressure, diastolic blood pressure, mean artery pressure levels before operation, immediately after intubation, immediately after extubation, immediately after extubation, incidence of adverse reactions of two groups before and after treatment were compared. Results: The Recovery time, first exhaust time, recovery time of spontaneous breathing, common food intake time, recovery time of bowel sounds in the observation group were significantly lower than those in the control group(P＜0.05). Postoperative 1H, postoperative 3h, postoperative 6h, postoperative 12h and postoperative 24hVAS scores were significantly lower than those of the control group(P＜0.05).Preoperative, intubation, immediate and immediate extubation of SBP, DBP and MAP were significantly lower than those of the control group(P＜0.05).The total incidence of adverse reactions was significantly lower than that of the control group[15.55%(7/45)vs34.21％(13/38)](P＜0.05). Conclusion: . Dexmedetomidine has remarkable analgesic effect after radical resection of colon cancer. It can improve analgesic and sedative effect, reduce fluctuation of vital signs, promote faster recovery of gastrointestinal function and reduce adverse reactions.
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2019, Vol. 25 
