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| Expression Levels of Cyclic RNA ciRS-7 and EGFR in Endometrial Carcinoma |
| AN Xin, et al |
| Handan First Hospital of Hebei Province, Hebei Handan 056000, China |
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Abstract Objective: To investigate the expressions and clinical significances of cyclic RNA ciRS-7 and epidermal growth factor receptor (EGFR) in endometrial cancer. Methods: 62 patients tissus with endometrial cancer who underwent surgical treatment in Handan First Hospital from July 2011 to May 2013 were studied, meanwhile, 60 normal endometrial tissues of hysteromyoma patients undergoing hysterectomy were collected as control group, real-time fluorescence quantitative polymerase chain reaction (qRT-PCR) was used to detected the expression levels of ciRS-7 and EGFR in all specimens, the correlation between the expressions of ciRS-7 and EGFR, and their relationships with clinicopathological characteristics and prognosis. Results: The expression levels of ciRS-7 and EGFR in the study group were significantly higher than those in the control group (P<0.05); the expression of ciRS-7 was not correlated with age and menopause (P>0.05), but with histological differentiation, pathological stage, myometrial invasion, and lymph node metastasis (P<0.05); the expression of EGFR was not related to age (P>0.05), but related to menopause, histological differentiation, pathological stage, myometrial invasion, and lymph node metastasis (P<0.05); the correlation analysis showed that there was a positive correlation between ciRS-7 and EGFR expression in endometrial cancer tissues (r = 0.875, P<0.001); the median survival time of patients with high expression of ciRS-7 was lower than that of patients with low expression (P<0.05), and the median survival time of patients with high expression of EGFR was lower than that of patients with low expression (P<0.05). Conclusion: The expressions of ciRS-7 and EGFR are high in endometrial cancer, they were positively correlated, and correlated with histological differentiation, pathological stage, myometrial invasion, lymph node metastasis, and prognosis, it is speculated that both of them can be used as potential biomarkers for prognostic evaluation of endometrial cancer.
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2019, Vol. 25 
