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| Clinical Efficacy of Self-made Qinggan Lishi Decoction in the treatment of Patients with Cervical Cancer Chemotherapy |
| ZUO Minfang |
| Second Affiliated Hospital of Hainan Medical College, Hainan Haikou 570311, China |
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Abstract Objective: To study the clinical efficacy of self-made Qinggan Lishi decoction in the treatment of patients with cervical cancer chemotherapy. Methods: 86 patients with cervical cancer chemotherapy who were admitted to our hospital from January 2016 to July 2017 were randomly divided into control group (43 cases) and observation group (43 cases). Control group was given paclitaxel/irinotecan chemotherapy regimen, and observation group was given self-made Qinggan Lishi decoction on the basis of control group. After 6 w of treatment, the tumor diameter, time required for chemotherapy, treatment effects, serum tumor markers levels, immune function, quality of life and adverse reactions were evaluated and analyzed in the two groups. Results: The tumor diameter in observation group after treatment was significantly reduced, and the total effective rate of treatment was higher than that in control group (81.39% vs 72.09%) (P<0.05). The serum levels of carbohydrate antigen 125 (CA125), squamous cell carcinoma antigen (SCCA) and carcinoembryonic antigen (CEA) were significantly decreased in observation group after treatment (P<0.05). The levels of immunoglobulin G ((IgG), immunoglobulin M (IgM) and immunoglobulin A (IgA), blood CD3+ and CD4+ cell ratios and CD4+/CD8+ ratio in the blood were increased significantly in observation group (P<0.05). The SF-36 scores in observation group after treatment were significantly higher than those in control group (P<0.05), and the incidence rate of adverse reactions of grade II-III was significantly lower than that in control group (P<0.05). The local recurrence rate and distant metastasis rate within 1 year of treatment were 4.65% and 2.33% in observation group, which were lower than those in control group with 11.63% and 4.65% (P<0.05). Conclusions: Self-made Qinggan Lishi decoction can effectively improve the clinical treatment effects of patients with cervical cancer chemotherapy.
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[1] 黄梦微,杜靖然,杨永秀.局部晚期宫颈癌的治疗现状与进展[J].现代妇产科进展,2018,27(9):713~715.
[2] 郭秀伟,张培彤,孙桂芝.孙桂芝诊疗宫颈癌经验浅析[J].辽宁中医杂志,2017,36(12):2514~2516.
[3] Zhu Y X,Li T,Fan S R,et al.Health-related quality of life as measured with the Short-Form 36(SF-36)questionnaire in patients with recurrent vulvovaginal candidiasis[J].Health&Quality of Life Outcomes,2016,14(1):1~6.
[4] 张翠兰.妇科肿瘤患者血清中HE4及CA125联合检测的临床意义[J].基因组学与应用生物学,2016,35(7):1604~1607.
[5] 王攀,蒋智钢,郑家深,等.血清鳞状细胞癌抗原、组织蛋白酶D和糖类抗原125检测对宫颈鳞癌诊断及预测转移的应用价值[J].中国现代医学杂志,2016,26(5):42~47.
[6] 曾丽,王群.中药联合常规化疗对乳腺癌术后患者免疫功能及远期转移复发率的影响[J].解放军医药杂志,2016,28(11):98~101. |
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2019, Vol. 25 
