|
|
|
| Clinical Value of Combined Detection of Serum Erythrocyte Distribution width Uric Acid and Brain Natriuretic Peptide in the Diagnosis of Chronic Heart Failure |
| LI Shuo, LI Baizhi, LI Xiaohui, et al |
| The Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China |
|
|
|
|
Abstract Objective: To explore the diagnostic value of combined detection of serum erythrocyte distribution width (RDW), uric acid (UA) and brain natriuretic peptide (BNP) levels in patients with chronic heart failure(CHF).. Methods: Eighty patients with CHF admitted to the Department of Cardiology, Affiliated Hospital of Chengde Medical College from August 2017 to June 2018 were selected as CHF group.Seventy-five patients with normal cardiac function were selected as control group.Peripheral blood samples were collected from patients.The baseline database was established.. Results:Compared with the control group, the levels of serum RDW, UA and BNP in CHF group were higher and positively correlated with the grading of cardiac function. With the increase of the grading of cardiac function, the levels of serum RDW, UA and BNP gradually increased, with statistical significance. ROC curve analysis showed that the area under the curve of serum RDW, UA and BNP was 0.744, 0.761 and 0.984, respectively. The area under the curve of combined detection of serum RDW, UA and BNP was 0.985, with statistical significance.. Conclusion: Combined detection of serum levels of RDW, UA and BNP can help clinicians better diagnose CHF in early stage, comprehensively evaluate the risk stratification of patients' condition, and provide objective and comprehensive diagnostic value.
|
|
|
|
|
|
[1] Hobbs FD,Roalfe AK,Davis RC,et al. Prognosis of all-cause heart failure and borderline left ventricular systolic dysfunction: 5 year mortality follow-up of the echocardiographic heart of england screening study (ECHOES)[J].Eur Heart[J].2007,28(9):1128~1134.
[2] Mantovani A,Targher G,Temporelli PL,et al.Prognostic impact of elevated serum uric acid levels on long-term outcomes in patients with chronic heart failure: a post-hoc analysis of the GISSI-HF (Gruppo italiano per lo studio della sopravvivenza nella Insufficienza cardiaca-heart failure) Trial[J].Metabolism,2018,83:205~215.
[3] 中华医学会心血管病学分会,中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2014[J].中华心血管病杂志,2014,42(2):98~122.
[4] Zheng YR,Ye LF,Cen XJ,et al.Low NT-proBNP levels: An early sign for the diagnosis of ischemic heart failure[J].International Journal of Cardiology,2017,228 :666~671.
[5] van Kimmenade RR, Mohammed AA, Uthamalingam S,et al. Red blood cell distributionwidth and 1-year mortality in acute heart failure[J].Eur Heart Fail,2010,12(2):129~136.
[6] Tonelli M, Sacks F, Arnold M, et al.Relation between red blood cell distribution width andcardiovascular event rate in people with coronary disease[J].Circulation,2008,117(2):163~168.
[7] Doehner W, von Haehling S, Anker SD. Uric acid as a prognosticmarker in acute heart failure: new expectations from an oldmolecule[J].Eur Heart Fail,2007,9(5):437~439. |
|
|
|
2019, Vol. 25 
