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| Application of GRACE Score Combined with Serum Lp-PLA2 and NT-proBNP Levels in Predicting MACE Events after PCI in Patients with AMI |
| WANG Suling, JIA Yongping, et al |
| The First Clinical Medical College of Shanxi Medical University, Shanxi Taiyuan 030001, China |
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Abstract Objective: To investigate the global acute coronary event registration score (GRACE) combined with serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) levels in patients with acute myocardial infarction (AMI) application value in the prediction of cardiovascular adverse events (MACE) after cortical coronary intervention (PCI). Methods: A total of 189 patients with acute myocardial infarction in our hospital (from November 2016 to March 2018) were enrolled. All patients were followed up for 6 months after PCI. 56 patients with myocardial infarction with MACE were assigned to MACE group, and the rest did not have MACE. Patients with myocardial infarction were set to non-MACE group. The general conditions of the two groups (gender, age, BMI, diastolic blood pressure, systolic blood pressure, history of heart failure, history of diabetes, heart rate) and GRACE scores were measured. Serum NT-proBNP levels were determined by double-antibody sandwich immunofluorescence assay. Serum Lp-PLA2 levels were determined by immunosorbent assay. The general conditions, GRACE scores, serum NT-proBNP, and Lp-PLA2 levels were statistically analyzed, and the risk factors associated with MACE in patients with acute myocardial infarction were statistically analyzed. Results: There were no significant differences in gender, age, BMI, diabetes history and non-MACE between the MACE group (P>0.05). The diastolic blood pressure, heart rate and heart failure and systolic blood pressure in the MACE group were lower than those in the non-MACE group(32.14%), higher than the Non-MACE group (3.76%) (P<0.05); GRACE score and serum NT-proBNP, Lp-PLA2 levels in MACE group were significantly higher than non-MACE group (P<0.05); Logistic multiple linear regression analysis showed that GRACE score ≥ 140 points, serum NT-proBNP level ≥1000 ng/nl, serum Lp-PLA2 level ≥210 ng/ml and the history of heart failure were important risk factors for MACE in patients with acute myocardial infarction (P<0.05). Conclusion: The GRACE score and the abnormal levels of serum NT-proBNP and Lp-PLA2 in patients with MACE after acute myocardial infarction have increased abnormalities, and the GRACE scores and serum NT-proBNP, Lp-PLA2 levels, and the history of heart failure are the important risk factors in patients with MACE. Clinical indicators can be used to predict the risk of MACE in patients with acute myocardial infarction after PCI, and to do the corresponding prevention and control work.
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2019, Vol. 25 
