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| Study on the Correlation between Dermatomyositis and Myositis-specific Antibodies in Children |
| DU Wanglei, LI Zhiqin, YANG Xichao, et al |
| Xijing Hospital of Air Force Medical College, Shaanxi Xi'an 710000, China |
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Abstract Objective: To investigate the clinical manifestations of juvenile dermatomyositis (JDM) and correlation with myositis specific autoantibodies (MSAs). Methods: 182 cases of JDM in our hospital from June 2012 to March 2018 were collected. MSAs were detected and the relationship between MSAs and clinical data was analyzed. Results: Among 182 children, 136 (74.73%) were MSAs positive. Anti-ARS, MDA51 and TIF1-gamma were the three most common subtypes. The positive rates were 20.88%, 18.68% and 18.13% respectively. Single factor analysis and logistic regression analysis showed that anti-NXP2 antibody positive [OR = 2.764, 95% CI (1.268-7.013), P = 0.013], anti-TIF1-gamma antibodpositive [OR = 2.812, 95% CI (1.567-4.923), P = 0.000, P = 0.000, P = 0.000] and anti-SAE antibodpositive [OR = 4.758, 95% CI (1.079-79-19.587, 95% CI (1.079-19.587-19.587), P = 0.035] were all independent risk factors for dysphagia in JDM children. Anti-NXP2, 95% CI (OR = 2, 95% CI (1.268-95% CI (1.95% CI (0.173-0.745), P = 0.006] did not. Easy to swallow disorders. Positive anti-Jo-1 antibody [OR = 6.321, 95% CI (1.684-20.357), P = 0.007] and anti-MDA5 (OR = 5.349, 95% CI (2.513-10.687), P = 0.003) were independent risk factors for interstitial lung disease (ILD) in JDM children. ILD was not easy to occur in patients with positive anti-Mi-2 antibody [OR = 0.213, 95% CI (0.068-0.579), P = 0.004] and anti-TIF1-gamma antibody [OR = 0.175, 95% CI (0.084-0.382), P = 0.000]. Conclusion: The positive rate of serum MSAs in children with JDM is high. Different MSAs subtypes are related to the related symptoms. The detection of MSAs is important for the diagnosis and treatment of diseases.
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2019, Vol. 25 
