恶性脑胶质瘤中1H-MRS与5-ALA荧光强度的相关性研究

doi:10.3969/j.issn.1006-6233.2019.04.033

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Abstract Objective: To investigate the correlation between the proton magnetic resonance spectroscopy (1H-MRS) and the 5-aminolevulinic acid (5-ALA) fluorescence intensity in malignant gliomas. Methods: From September 2012 to January 2018. 32 patients with malignant glioma were selected, all the patients were examined by 1H-MRS and 5-ALA fluorescence intensity, and were given the correlation analysis. Results: In the 32 patients, the conventional MRI were showed uneven enhancement, high signal around T2, unclear tumor border and significant edema around the tumor. The typical spectrum of tumor parenchyma of glioma were showed significant reduction in NAA peak, Cho peak significantly were increased, Cr peak were decreased not significantly, the Cho/NAA, Cho/Cr ratio were increased, NAA/Cr ratio were decreased, and compared the contralateral normal region were statistically significantly difference (P<0.05). The Cho/NAA, Cho/Cr and NAA/Cr ratios in the low level group were also significantly different from those in the high level group (P<0.05). The PpIX fluorescence intensity in the tumor parenchyma of glioma were 2.79±0.49, and the contralateral normal area were 1.84±0.51, so the tumor parenchyma region were significantly higher than that of the contralateral normal region (t=6.398, P=0.008). The Pearson coefficient analysis showed that the fluorescence intensity of PpIX in the tumor parenchyma were negatively correlated with NAA/Cr (P<0.05), and were significant positive correlation with Cho/Cr and Cho/NAA (P<0.05). Conclusion: There was a significant correlation between 1H-MRS and 5-ALA fluorescence intensity in malignant glioma.

Key words： Malignant glioma Proton magnetic resonance spectroscopy 5-aminolevulinic acid

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.04.033 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I4/651

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