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| Effects of Dexamethasone Combined with Methylprednisolone Sodium Succinate on Neurological Function NSE NO and NE after Craniotomy for Traumatic Brain Edema |
| GAO Peng, WANG Peng, et al |
| Xi'an High Tech Hospital, Shaanxi Xi'an 710075, China |
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Abstract Objective: To study the effects of dexamethasone combined with methylprednisolone sodium succinate on neurological function, NSE, NO and NE after craniotomy for traumatic brain edema. Methods: Fifty patients with traumatic brain edema admitted to our hospital from August 2016 to July 2017 were randomly divided into observation group and control group with 25 cases in each group. The control group was treated with dexamethasone after craniotomy, while the observation group was treated with methylprednisolone sodium succinate. The clinical efficacy, brain edema volume and neurological function, levels of NSE, NO and NE were compared between the two groups. Results: After treatment, the total clinical effective rate of the observation group was significantly higher than that of the control group (P<0.05). Before treatment, there was no significant difference in the volume of brain edema and NIHSS score between the two groups (P>0.05). The volume of brain edema and NIHSS score of the two groups showed a downward trend on the 3rd, 7th and 14th day after treatment. The volume and NIHSS score of the observation group were significantly lower than those of the control group on the 3rd, 7th and 14th day after treatment (P<0.05). The two groups were compared in the aspects of group, time point and time point. There were significant differences (P<0.05). Before treatment, there was no significant difference in NSE, NO and ET levels between the two groups (P>0.05). After treatment, the NSE levels of the two groups showed an upward trend on the 3rd and 7th day. After treatment, the NSE levels of the two groups showed a downward trend on the 14th day. After treatment, the levels of NO and ET of the two groups showed a downward trend. The observation group was significantly lower than the control group on the 3rd, 7th and 14th day (P<0.05). There were significant differences in different time points, between groups and at different time points (P<0.05). Conclusion: Traumatic brain edema patients treated with dexamethasone combined with methylprednisolone sodium succinate after craniotomy can effectively improve brain edema and neurological function, effectively reduce the levels of NSE, NO and NE, and have good clinical efficacy.
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2019, Vol. 25 
