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| Efficacy of Baitangping combined with Liraglutide in the treatment of Type 2 Diabetes Mellitus and its Effect on Serum Hcy and APN |
| HU Wenhua, WANG Weiwei, WANG Yonglin |
| Yangling Demonstration hospital, Shaanxi Xianyang 712100, China |
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Abstract Objective: To investigate the efficacy of Baitangping combined with Liraglutide in the treatment of type 2 diabetes mellitus and its effect on serum homocysteine (Hcy) and adiponectin (APN). Methods: 95 patients with type 2 diabetes admitted to our hospital from March 2016 to March 2017 were selected, 50 cases were randomly divided into observation group and 45 cases in control group, according to the simple random grouping method. The observation group was treated with baitangping and lilalutin. The control group was treated with metformin. Compare the clinical efficacy of two groups of patients, fasting blood sugar, 2 h postprandial blood glucose, and glycosylated hemoglobin (HbAlc), serum creatinine, serum creatinine, Scr) and glomerular filtration rate (glo - merular filtration rate, GFR), Hcy, APN levels; Body mass index and adverse reactions were recorded before and after treatment. Results: After treatment, the effective rate of the observation group was 94.00%, significantly higher than that of the control group (P<0.05). Before treatment, there was no significant difference in the level of each indicator between the two groups. After treatment, the level of each indicator decreased in both groups, compared with that before treatment (P<0.05). Fasting blood glucose, 2h postprandial blood glucose and HbAlc in the observation group were all lower than those in the control group (P<0.05). There was no significant difference in Scr, GFR level and body mass index between the two groups before treatment. After treatment, the Scr level and body mass index of the observation group were significantly lower than that of the control group, and the GFR level was higher than that of the control group (P<0.05). There was no significant difference in serum Hcy and APN levels between the two groups before treatment. After treatment, the serum Hcy level of the two groups significantly decreased and the APN level significantly increased, and the serum Hcy level of the observation group was significantly lower than that of the control group, and the APN level was significantly higher than that of the control group (P<0.05). The incidence of hypoglycemia in the observation group was significantly lower than that in the control group (P<0.05). There was no statistically significant difference in the incidence of nausea, vomiting, headache and diarrhea between the two groups (P>0.05). Conclusion: Baitangping combined with liraglutide is effective in the treatment of type 2 diabetes mellitus. It can significantly improve the level of serum Hcy and APN without increasing the occurrence of adverse reactions. The patients can basically tolerate it. It is worth popularizing and applying.
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2019, Vol. 25 
