|
|
|
| Effect of Chlorhexidine Gargle combined with Orthodontic treatment on Anterior Teeth Displacement caused by Periodontal Disease and its Influence on Serum Levels of IL-2 IL-6 and TNF-alpha |
| ZHANG Xiaoyu, TIAN Li, et al |
| The First People's Hospital of Guangyuan, Sichuan Guangyuan 628017, China |
|
|
|
|
Abstract Objective: To investigate the effect of chlorhexidine gargle combined with orthodontic treatment on anterior teeth displacement caused by periodontal disease and the effects of chlorhexidine gargle on serum levels of interleukin-2, interleukin-6 and tumor necrosis factor-alpha. Methods: 108 patients with anterior teeth displacement caused by periodontal disease were selected from January 2015 to January 2018 in our hospital. They were divided into two groups by simple random number table. The control group (54 cases) was treated with orthodontic treatment, while the observation group (54 cases) was treated with chlorhexidine mouthwash. The clinical efficacy, periodontal indexes, serum levels of IL-2, IL-6 and TNF-alpha, and adverse reactions were compared between the two groups before and after treatment. Results: After receiving treatment for 12 months, overall effective rate of observation group was 94.4% which was significant higher than control group's 81.5% (P<0.05). After receiving treatment for 12 months, Two groups' periodontal index including probing bleeding rate, anterior teeth covering, periodontal pocket depth values and serum IL-2, IL-6 and TNF-α decreased significantly if comparing with those before treatment (P<0.01), and observation group's above index decreased more significantly (P<0.01). Serum IL-2 of two groups' increased significantly after receiving treatment for 12 months if comparing with that before treatment (P<0.01). Observation group's serum IL-2 was significant higher after treatment if comparing with control group at same time (P<0.01). There was no statistical significance if comparing control group adverse reaction rate (13.0%) with observation group's (9.3%) (P>0.05). Conclusion: The treatment of anterior teeth displacement caused by periodontal disease with chlorhexidine mouthwash combined with oral malformation can effectively regulate the level of inflammatory cytokines in patients, improve periodontal status and have significant clinical effects.
|
|
|
|
|
|
[1] 马璞玉,吴豪阳.口腔正畸固定矫治技术治疗牙槽突骨折的疗效[J].郑州大学学报(医学版),2017,52(2):167~169.
[2] 舒丹.电针对口腔正畸牙痛患者血清Wnt3a、Wnt5a及护骨素的影响[J].中国老年学杂志,2016,36(10):2476~2477.
[3] 张文玲,薛鹏,赵勇,等.口腔正畸治疗对口腔中细菌微生态影响的临床分析[J].江苏医药,2014,40(9):1095~1096.
[4] 赖力,田蕾蕾,莫宏,等.对比氯已定和聚维酮碘预防手术伤口感染疗效的随机对照临床研究[J].四川大学学报(医学版),2017,48(3):500~502.
[5] Rong W U. Effect of Jinzhi Jieyin Gargle on the treatment of moderately severe periodontitis[J].Changchun University Tradit Chin Med, 2014,15(22):48~50
[6] 舒丹.口腔正畸改建术对患者血清β-EP、5-HT影响及康复新液对治疗后牙痛的疗效研究[J].辽宁中医杂志,2016,43(5):988~991.
[7] 邓昊,周立辉,鲜文,等.口腔正畸治疗牙周病致前牙移位的临床疗效观察[J].现代生物医学进展,2015,15(9):1732~1734,1743.
[8] Niedzielska I, Chudek J, Kowol I, et al. The odontogenic-related microinflammation in patients with chronic kidney disease.[J]. Ren Fail, 2014, 36(6):883~888.
[9] 王佳宁.氧化锆氧化铝陶瓷复合材料对人牙周膜细胞增殖、凋亡和骨诱导活性的影响[J].中国组织工程研究,2017,21(26):4155~4159.
[10] 孟琨.康复新液对口腔正畸所致慢性牙龈炎临床疗效及对牙龈肿胀及疼痛改善情况的影响[J].基因组学与应用生物学,2018,37(3):996~1001. |
|
|
|
2019, Vol. 25 
