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| Relationship between HPV16/18 Infection and Expression of PDGFR- and PDGFR- beta Protein in Cancer Tissues of Elderly Patients with Cervical Squamous Cell Carcinoma |
| ZHANG Yufang, REN Chunli, HOU Jing, et al |
| The Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China |
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Abstract Objective: The relationship between the expression of HPV16/18 infection and the expression of platelet derived growth factor receptor alpha (platelet-derived growth factor receptor-alpha, PDGFR- a) and platelet derived growth factor receptor beta (platelet-derived growth factor receptor-alpha, PDGFR- beta) in the elderly patients with squamous cell carcinoma of the cervix and the expression of platelet derived growth factor receptor beta (platelet-derived growth factor receptor-alpha, PDGFR- beta) and the relationship between the three The relationship between each other.Methods:75 cases of senile cervical squamous cell carcinoma and 32 of normal cervical tissue were selected. In situ hybridization was used to detect HPV16 /18 infection, and PDGFR- A and PDGFR- beta protein were detected by immunohistochemistry. Results:The infection rates of HPV16 /18 in cervical squamous cell carcinoma group and control group were 69.33% (52 /75) and 18.75% (6 /32) respectively.The infection rate of HPV16 /18 in elderly patients with cervical squamous cell carcinoma was significantly higher than that in the control group (P <0. 05). One case of PDGFR-α protein expression was detected in the control group, Positive expression rate 3.13%. In the elderly patients with cervical squamous cell carcinoma, 59 cases of PDGFR-α protein were detected positively, Positive expression rat 78.67%, and the difference was statistically significant. (P<0.05); The positive expression rate of PDGFR-α protein was related to the clinical stage of cervical squamous cell carcinoma patients (P<0.05); The positive expression rate of PDGFR-β protein was lower in the control group was 6.25%, and the cervical squamous cell carcinoma patients The expression rate of PDGFR-β protein in tissues was 62.67%, and the difference was statistically significant (P<0.05). The expression of PDGFR-β protein was correlated with the clinical stage of cervical scales (P<0.05); Among 72 cases of cervical squamous cell carcinoma, 47 cases (Positive expression rat 62.67%) were HPV16/18 positive, 45 cases (Positive expression rat 95.74%) were PDGFR-α protein positive, 40 cases (Positive expression rat 85.11%) were PDGFR-β protein positive.The number of HPV16/18 positive cervical squamous cell carcinoma patients was significantly higher than that of non-HPV16/18 positive cervical squamous cell carcinoma patients (P < 0.05).Spearman correlation analysis showed that the expression of PDGFR-α and PDGFR-β protein was positively correlated with HPV16/18 infection in patients with cervical cancer (rs=0.428,P<0.05; rs=0.562,P<0.05).PDGFR-α was positively correlated with the expression of PDGFR-β protein in cervical cancer patients (rs=0.639, P<0.05).Conclusions:Senile cervical squamous cell carcinoma is closely related to HPV16/18 infection. The expression of PDGFR-α and PDGFR-β protein in HPV16/18 infected cervical squamous cell carcinoma is significantly increased.It plays a synergistic role in the occurrence and development of cervical squamous cell carcinoma
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2019, Vol. 25 
