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| Clinical Efficacy of Isoniazid Combined with Glucocorticoid in the treatment of Tuberculous Pleurisy |
| HUANGFU Tong, et al |
| 3201 Hospitals in Hanzhoung, Shaanxi Hanzhoung 723000, China |
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Abstract Objective: To observe the clinical efficacy of isoniazid combined with glucocorticoids in the treatment of tuberculous pleurisy. Methods:120 patients with tuberculous pleurisy admitted to the infections department of the hospital from June 2016 to March 2018 were chosen and divided into two groups by simple randomization method. The control group (n=60) was given conventional anti-tuberculosis treatment and chest drainage, the observation group (n=60) was given transthoracic injection of isoniazid combined with glucocorticoid on the basis of conventional treatment; the clinical efficacy, symptom improvement status, and lung function index[lung capacity percentage taking estimated value (VC%pred), forced lung capacity percentage taking estimated value(FVC%pred), total lung volume as a percentage of predicted value (TLC%pred)] changes before and after treatment and inflammatory factors in pleural effusion [transforming growth factor-β1 (TGF-β1), interleukin-6 (IL-) 6), tumor necrosis factor-α (TNF-α)] changes were compared between the two groups. Results: The effective rate of treatment in the observation group (91.67%)was significantly higher than in the control group (76.67) (P<0.05). The changes of pleural effusion and pleural thickness in the observation group were significantly more than those in the control group (P<0.05), and the pleural fluid absorption time was significantly shorter than that in the control group (P<0.05), the incidence of pleural thickening was significantly lower than that in the control group (P<0.05). After treatment, the increase of VC%pred, FVC%pred, TLC%pred and the decrease of TGF-β1, IL-6 and TNF-α levels in the observation group were significantly higher than those in the control group (P<0.05). Conclusion: Intrathoracic injection of isoniazid combined with glucocorticoids is effective in the treatment of tuberculous pleurisy, which can promote the loss of pleural effusion and reduce the occurrence of pleural hypertrophy
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2019, Vol. 25 
