|
|
|
| Changes and Clinical Significance of Serum CXCL16, GDF15, Lp-PLA2 Levels in Patients with Acute Cerebral Infarction |
| LIU Xiqi, et al |
| Cangzhou Central Hospital, Hebei Cangzhou 061001, China |
|
|
|
|
Abstract Objective: To investigate the expression levels of serum CXCL16, GDF15 and Lp-PLA2 in patients with acute cerebral infarction (ACI) and its clinical significance. Methods: 100 patients with acute cerebral infarction (study group) and 100 healthy subjects (control group) were enrolled in our hospital from January 2016 to March 2018. The clinical data of patients were collected and ACI patients were performed according to TOAST. Grouping. The levels of CXCL16, GDF-15 and Lp-PLA2 in the serum of patients were detected by enzyme-linked immunosorbent assay and statistical analysis was performed. Results: Univariate analysis showed that there was a significant difference in the levels of hypertension, diabetes, hyperlipidemia, CXCL16, GDF15 and Lp-PLA2 between the ACI group and the control group (P<0.05). Serum CXCL16 levels in ACI patients were associated with BMI (P=0.001), hypertension (P=0.018), hyperlipidemia (P=0.044), and NIHSS score at admission (P=0.004); GDF15 and diabetes (P=0.042) Hyperlipidemia (P=0.005) and NIHSS score (P=0.003) at admission; Lp-PLA2 and BMI (P=0.046), hyperlipidemia (P=0.040), and NIHSS score at admission (P=0.046) related. Compared with other ACI subtypes, patients with large atherosclerosis (LAA) had the highest levels of serum CXCL16, GDF15, and Lp-PLA2 (3.64±0.63, 1338.12±513.31, 344.52±134.26, respectively), and there were statistical differences (P<0.05). Conclusion: The elevated levels of serum CXCL16, GDF-15 and Lp-PLA2 are risk factors for acute ischemic stroke.
|
|
|
|
|
|
[1] Ossi RG, Meschia JF, Barrett KM. Hospital-based management of acute ischemic stroke following intravenous thrombolysis[J]. Expert Rev Cardiovasc Ther, 2011, 9(4):463~472.
[2] Van Os HJ, Mulder IA, van der Schaaf IC, et al. Role of atherosclerosis, clot extent, and penumbra volume in headache during ischemic stroke[J]. Neurology, 2016, 87 (11):1124~1130.
[3] O’Neal WT, Kamel H, Zhang ZM, et al. Advanced interatrial block and ischemic stroke: the Atherosclerosis Risk in Communities Study[J]. Neurology, 2016, 87 (4):352~356.
[4] Pant S, Deshmukh A, Gurumurthy GS, et al. Inflammation and atherosclerosis--revisited. [J].Cardiovasc Pharmacol Ther., 2014, 19(2):170~178.
[5] Ma A, Yang S, Wang Y, et al. Increase of Serum CXCL16 Level Correlates Well to Microembolic signals in Acute Stroke Patients with Carotid Artery Stenosis [J]. Clinica Chimica Acta, 2016, 460: 67~71.
[6] Xiang Y, Zhang T, Guo J, et al. The Association of Growth Differentiation Factor-15 Gene Polymorphisms with Growth Differentiation Factor-15 Serum Levels and Risk of Ischemic Stroke[J].Stroke Cerebrovasc Dis, 2017, 26(10):2111~2119.
[7] 王勇,徐锐,赖红梅,等.血浆生长分化因子-15与急性冠状动脉综合征患者预后的关系[J].中华实用诊断与治疗杂志,2017,1:42~44.
[8] Wei L, Ke Z, Zhao Y, et al. The elevated lipoprotein-associated phospholipase A2 activity is associated with the occurrence and recurrence of acute cerebral infarction[J]. Neuroreport, 2017, 28(6):325~330. |
|
|
|
2019, Vol. 25 
