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| Effects and Adverse Reactions of Dexmedetomidine Combined with Combined Spinal-epidural Anesthesia on Sedative Effects in Pregnant Women Undergoing Cesarean Section |
| HE Jun, CHEN Jie, WANG Yongshun, et al |
| General Hospital of Hanjiang Oilfield, Hubei Qianjiang 433124, China |
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Abstract Objective: To explore the sedative effects and adverse reactions of dexmedetomidine combined with combined spinal-epidural anesthesia on pregnant women undergoing cesarean section. Methods: 68 cases of pregnant women with cesarean section admitted to our hospital from January 2017 to September 2018 were selected for the study and were given simple random grouping by the random number table, and were divided into observation group and control group, with 34 cases in each group. The two groups were given combined spinal-epidural anesthesia, and observation group was given ropivacaine+dexmedetomidine, and control group was given ropivacaine+normal saline. Mean arterial pressure (MAP), heart rate (HR), oxygen saturation (SpO2) and Ramsay sedation score were recorded before anesthesia (T1), after 5 min (T2) and 20 min (T3) of anesthesia and at fetal delivery (T4). And the neonatal Apgar score and NBNA score were compared between the two groups, and the occurrence of maternal adverse reactions was recorded. Results: The MAP and HR at time points of T2, T3 and T4 in control group were lower than those at T1, and lower than those in observation group (P<0.05). There were no statistically significant differences in the MAP and HR in observation group and SpO2 in the two groups before and after anesthesia (P>0.05). There were no significant differences in the Ramsay sedation scores between the two groups at T1 and T2 (P>0.05), and the Ramsay sedation scores at T3 and T4 in observation group were higher than those in control group (P<0.05). There were no significant differences in the Apgar score at 1min and 5min after delivery, NBNA score at 2d and 7d after delivery and incidence rate of maternal adverse reactions between the two groups (P>0.05). Conclusions: Dexmedetomidine combined with combined spinal-epidural anesthesia has good sedative effects on pregnant women with cesarean section, and it is beneficial to maintain intraoperative hemodynamic stability, and has small adverse effects on puerperae and neonates, and it has good safety.
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2019, Vol. 25 
