早产儿脑白质损伤中辅助性T细胞表达失衡及NF-κB的变化

doi:10.3969/j.issn.1006-6233.2019.11.014

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Abstract Objective: To demonstrate the expression of T helper cell 1 (Th1), T helper cell 2 (Th2) and nuclear factor-κB (NF-κB) in premature infants with white matter injury (WMI). Methods: Serum samples were collected from 70 WMI neonates, plus another control group of 70 premature babies without WMI. Patients were further divided into mild, moderate and severe WMI groups. Reverse transcription quantitative polymerase chain reaction was used to test mRNA expression levels of Th1/Th2 cytokines, including interleukin 2 (IL-2), tumor necrosis factor- α (TNF-α ), IL-4,IL-10 and nuclear factor (NF)- κB, whilst their serum levels were measured by ELISA. Results: Serum levels of IL-4 and IL-10 were significantly decreased in premature WMI babies, whilst IL-2, TNF-α and NF-κB were upregulated (P<0.05 vs. control group). With aggravated disease, IL-4 and IL-10 expression was further decreased while IL-2, TNF-α and NF-κB were increased (P<0.05 vs. mild WMI group). Th1 cytokines IL-2 and TNF-α and NF-κB were negatively correlated with Th2 cytokines IL-4 and IL-10. Disease severity was positively correlated with IL-2, TNF-αand NF-κB expression, and was negatively correlated with IL-4 and IL-10 (P<0.05). Conclusion: Upregulation of Th1/Th2 imbalance NF-kappa B may be a potential factor involved in the pathogenesis of WMI in premature infants for early diagnosis and treatment.

Key words： White matter injury T helper cell Nuclear factor-κB

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	Articles by authors
	SU Xuewen
	ZHU Hua
	YUAN Haifeng

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SU Xuewen,ZHU Hua,YUAN Haifeng. Expression Imbalance of Helper T cells and the Change of NF - κ B in Premature Infants with White Matter Injury[J]. HeBei Med, 2019, 25(11): 1813-1817.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.11.014 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I11/1813

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