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| Clinicopathological Features and Risk Factors of Bone Metastases in 60 Patients with Radical Resection of Colorectal Cancer |
| SHEN Xin, et al |
| General Hospital of Jinan Military Region, Shandong Jinan 250031, China |
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Abstract Objective: To analyze the clinicopathological features and risk factors of bone metastases in 60 patients with radical resection of colorectal cancer. Methods: The clinical data of 60 cases with bone metastases and 65 cases without bone metastases after radical resection of colorectal cancer in our hospital from June 2014 to June 2017 were retrospectively analyzed. The clinicopathological features and risk factors of 60 patients with postoperative bone metastasis were analyzed. Results: Among the 60 patients with bone metastasis after radical resection of colorectal cancer, most of them were middle-aged and elderly patients, mostly men. There were 16 cases (26.67%) of bone metastasis and 44 cases (72.33%) of multiple bone metastases. Bony changes: there were 50 cases (83.33%) of osteolytic lesions, 4 cases (6.67%) of osteogenic lesions and 6 cases (10.00%) of mixed bone destruction. There were 5 cases of simple bone metastases (8.33%), and 55 cases (91.67%) of combined distant metastasis. There were significant differences between patients with bone metastases and patients without bone metastases in terms of primary tumor location, infiltration depth, primary tumor diameter, whether postoperative chemotherapy was or not, preoperative CA199 level, whether lymph node metastasis was or not, and whether the combined lung metastasis was or not (P<0.05). The primary tumor location, infiltration depth, without postoperative chemotherapy, preoperative CA199 level, lymph node metastasis and lung metastasis were independent risk factors for bone metastases after radical resection for colorectal cancer (P<0.05). Conclusions: The location of primary tumors, depth of invasion, non-chemotherapy after operation, preoperative CA199 level, lymph node metastasis and lung metastasis are independent risk factors for bone metastasis in patients with colorectal cancer after radical operation. The monitoring of risk factors after operation should be strengthened, and corresponding preventive measures should be taken actively.
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2019, Vol. 25 
