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| Relationship between Brain Natriuretic Peptide Level and Depression in Patients with Acute ST-segment Elevation Myocardial Infarction |
| DUAN Huaying, DING Zhenjiang, NIE Jinxin, et al |
| Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China |
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Abstract Objective: To investigate the relationship between the relationship between the BNP level and depression in the acute st segment of the myocardial infarction.Methods: 308 cases of patients in the department of cardiology of the affiliated hospital of chengde medical college with acute st-segment elevation myocardial infarction was enrolled in this study.They were divided into the group of BNP greater than 100pg/ml 124 cases and the group of BNP less than 100pg/ml 184 cases according to BNP level.The patients in the two groups were evaluated on the PHQ-9 scale within72h after admission, and the patients with depression were divided into mild depression, moderate depression, moderate and severe depression and severe depression according to their scores.The proportion of people without depression and the proportion of people with different degrees of depression in the two groups were analyzed.Results: The proportion of patients in the BNP ≥ 100pg/ml group was higher than that in the BNP＜ 100pg/ml group (P<0.001).The proportion of depression in BNP ≥ 100pg/ml group was 79.8%, including 47.6% for mild depression, 22.6% for moderate depression, 8.0% for moderate and severe depression, and 1.6% for severe depression;the proportion of depression in BNP < 100pg/ml group was 60.9%, including 44.6% for mild depression, 12.5% for moderate depression, 3.3% for moderate and severe depression, and 0.5% for severe depression (P < 0.001).Linear regression analysis of BNP level and depression score showed that BNP level was positively correlated with depression score (r = 0.45, P < 0.001).Binary logistic regression showed that BNP level was an independent predictor of depression and the probability of depression in BNP > 100pg/ml group was higher than that in BNP < 100pg/ml group [adjust OR =2.09, 95%CI (1.19-3.67), P = 0.01]. Conclusion: The BNP level of patients with acute ST elevation myocardial infarction is closely related to depression. The higher the BNP level, the higher the proportion of people with depression, Depression was positively correlated with BNP level.
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2019, Vol. 25 
