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| Screening Value of Serum Sex Hormones PRL FSH LH T and E2 for Non-chimeric Klinefelter Syndrome |
| LI Min, TONG Fangfang |
| Qianjiang Central Hospital of Hubei, Hubei Qianjiang 433199, China |
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Abstract Objective: To analyze the screening value of serum sex hormones pituitrin (PRL), follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T) and estradiol (E2) for non-chimeric klinefelter syndrome. Methods: 140 cases of non-chinmeric klinefelter syndrome patients who treated from January 2013 to January 2018 in our hospital, and 98 cases of male infertility with normal chromosome karyotype at the same time were randomly selected as the control group. The levels of serum sex hormones PRL, FSH, LH, T and E2 in both groups were compared, and analyze the screening value of the ROC curve for each indicator. Results: Levels of PRL, FSH, LH and E2 in non-chimeric klinefelter syndrome group were higher in the than the control group (11.34±1.90)vs(8.01±1.14)ng/mL,(25.71±4.30)vs(9.60±1.57)mIU/mL,(23.18±3.21)vs(5.79±0.85)mIU/mL,(22.09±3.86)vs(18.43±2.40)pg/mL, and levels of T in non-chimeric patients group was lower than those in the control group (all P<0.05). The ROC curve shows that the area under the curve of PRL and FSH, LH, T and E2 was 0.725, 0.690, 0.656, 0.774 and 0.663, the area under the combined measurement curve was significantly higher than that of a single index (P<0.05). Conclusion: serum sex hormone PRL, FSH, LH, T and E2 levels have certain diagnostic value for non-chimeric klinefelter syndrome and can be used as a preliminary screening index for such diseases, providing a basis for clinical diagnosis.
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2019, Vol. 25 
