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| Exploration on Curative Effect of Different Thrombolytic Time of Ateplase on Serum PRDX1 and LPA in patients with Acute Ischemic Stroke |
| HE Yuanfa, CAO Qun, GAO Hong'an |
| Benxi Central Hospital, Liaoning Benxi 117000, China |
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Abstract Objective: To investigate the effects of different thrombolytic time of ateplase on serum peroxidoreduct protein 1 (PRDX1) and lysophosphatidic acid (LPA) in patients with acute ischemic stroke. Methods: 400 cases of acute ischemic stroke patients admitted to our hospital from June 2013 to June 2018 were selected as the study subjects, among them, 150 patients with onset to administration time < 3h were set as group A. 130 patients who were given medicine for 3~4.5h were set as group B. 120 patients received routine treatment at > 4.5h from onset to hospitalization were set as group C. Observe the clinical effect after treatment, serum PRDX1, LPA level, obstruction recanalization, 1 month after treatment three sets of the scale for assessment of modified Barthel index (MBI) evaluation of daily life activities ability, the United States national institutes of health stroke scale (NIHSS) scores. Results: After treatment, the total clinical efficacy rate of group A was 88.00% higher than 70.77% of group B and 53.33% of group C (P<0.05). There was no significant difference in serum PRDX1 and LPA between the three groups before treatment. After treatment, serum PRDX1 and LPA levels of the three groups decreased significantly, and serum PRDX1 and LPA levels of group A were significantly lower than those of group B and group C (P<0.05). After treatment, the good rate of vascular recanalization in group A was 78.00%, significantly higher than 58.46% in group B and 42.50% in group C (P<0.05). There was no significant difference in NIHSS and MBI scores between the three groups before treatment. After treatment, the MBI score of the three groups increased significantly, and the NIHSS score decreased significantly. Moreover, the MBI score of group A was significantly higher than that of group B and group C, and the NIHSS score was significantly lower than that of group B and group C (P<0.05). Conclusion: The early use of atpase in patients with acute ischemic stroke has a significant effect, which can improve the serum PRDX1 and LPA levels and quality of life of patients, which is worthy of clinical promotion.
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2019, Vol. 25 
