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| Curative Efficacy of Levonorgestrel Sustained Release System Combined with Triptorelin in Treatment of Adenomyosis of the Uterus and its Effect on Serum CA125 CA199 and HE4 |
| FENG Huaping, ZHAO Shaojie, TANG Yan |
| Wuxi Maternal and Child Health Care Hospital, Jiangsu Wuxi 214000, China |
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Abstract Objective: To investigate the efficacy of levonorgestrel sustained-release system combined with triptorelin in the treatment of adenomyosis and its effects on serum carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199) and human epididymal protein 4 (HE4). Methods: 88 patients with adenomyosis in our hospital were selected as the study subjects from April 2015 to April 2017, the randomized table method was used to divide the treatment group into the observation group (n=40) and the control group (n=48). The control group was treated with levonorgestrel sustained release system, and the observation group was treated with levonorgestrel sustained release system combined with triptorelin. The therapeutic effect and serum CA125, CA199 and HE4 levels, uterine volume, dysmenorrhea score, menstrual volume score and adverse reactions were compared between the two groups after treatment. Results: After treatment, the rate of annulus removal and irregular vaginal bleeding in the observation group were lower than those in the control group (P<0.05), and the relief of dysmenorrhea and the improvement of menstruation were higher than those in the control group (P<0.05). There was no significant difference in serum CA125, CA199 and HE4 levels between the two groups before treatment. After treatment, serum CA125, CA199 and HE4 levels of both groups decreased significantly, and serum CA125, CA199 and HE4 levels of the observation group were significantly lower than those of the control group (P<0.05). There was no significant difference in uterine volume, dysmenorrhea score and menstrual volume score between the two groups before treatment. After treatment, the uterine volume, dysmenorrhea score and menses score of the two groups decreased significantly, and the uterine volume, dysmenorrhea score and menses score of the observation group were significantly lower than those of the control group (P<0.05). The total incidence of adverse reactions in the observation group was 10.00%, significantly lower than the control group's 35.42% (P<0.05). Conclusion: In patients with adenomyosis, the use of levonorgestrel sustained release system combined with triptorelin has a significant effect, which can effectively improve the serum CA125, CA199 and HE4 levels of patients, and is worthy of promotion and application.
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2019, Vol. 25 
