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| The Effect of 3D-CRT and VMAT on Thyroid Function in Patients with Head and Neck Cancers |
| ZHANG Jun, LI Gang, REN Biyong, et al |
| Central Hospital of Chongqing Three Gorges tumor branch / Chongqing Three Gorges Tumor Prevention and Treatment Institute, Chongqing 404000, China |
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Abstract Objective: To study the effects of three-dimensional conformal radiation therapy (3D-CRT) and volume modulated arc therapy (VMAT) on thyroid function in patients with head and neck cancers. Methods: 140 patients with head and neck tumors from January 2011 to June 2014 underwent radiotherapeutics in Nuclear Medicine Department of Central Hospital of Chongqing Three Gorges Tumour Branch were randomly divided into group 3D-CRT and group VMAT, with 70 cases in each group, group 3D-CRT was treated with 3D-CRT, group VMAT was treated with VMAT, all patients were treated for 2 months and followed up for 24 months. The clinical efficacy at 2 months after radiotherapy was observed, the levels of serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) were measured before radiotherapy, at the end of radiotherapy, and at 3, 6, 12, 18 and 24 months after radiotherapy, QLQ-H&N35 scale score was used to evaluate the quality of life of patients before radiotherapy, 1 months for radiotherapy, after radiotherapy and 6 months after radiotherapy, the occurrence of hypothyrea during follow-up was recorded. Results: There was no significant difference in the total effective rate between the two groups at 2 months after radiotherapy (P>0.05); at 6, 12, 18 and 24 months after radiotherapy, the TSH in group VMAT was significantly lower than that in group 3D-CRT (P<0.05);at 12,18 and 24 months after radiotherapy, the FT3 and FT4 in group VMAT were significantly higher than those in group 3D-CRT (P<0.05); at 6 months after radiotherapy, the score of QLQ-H&N35 scale in group VMAT was significantly lower than that in group 3D-CRT (P<0.05); there was no significant difference in the incidence rate of hypothyrea between the two groups during the 24 months follow-up (P>0.05). Conclusion: 3D-CRT and VMAT are effective radiotherapy methods for head and neck cancers, but VMAT is superior to 3D-CRT in protecting thyroid function and improving quality of life after treatment.
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2018, Vol. 24 
