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| Effect of Cyclosporine Combined with Methylprednisolone Sodium Succinate on Serum Fibrosis Index and Urinary Beta 2-MG and mALB in Patients with Paraquat-induced Pulmonary Fibrosis |
| FU Zhibin, WANG Zhenzhen |
| Chengdu Military Area Government Hospital, Sichuan Chengdu 610000, China |
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Abstract Objective: To study effect of cyclosporine combined with methylprednisolone on paraquat induced pulmonary fibrosis in patients with serum fibrosis index and its effects on urine Urinary beta 2- microspheres (beta 2-MG) and microalbuminuria (mALB). Methods: 102 patients of paraquat induced pulmonary fibrosis who received therapy from Apr. 2015 to Apr. 2017 in our hospital were selected as research objects. According to draw method, all the patients were divided into the experimental group (n=50) and the control group(n=52). Two groups were given gastrointestinal lavage, nutritional supplements, analgesia, antibiotics, infection prevention and other conventional treatment, while the experimental group was on this basis, treated with cyclosporine combined with methylprednisolone, cyclosporin injection every time 5mg/kg, methylprednisolone every time 1000mg, once a day, after 4 days of treatment, decrease. Then serum fibrosis markers Hyaluronic acid (HA), laminin (LN), type IV collagen (CIV) and type III procollagen, Matrix metalloproteinase-9 (MMP-9) and matrix metalloproteinase inhibitor (T1MP-1) levels, urinary beta 2-MG, mALB levels, and Pulmonary high-resolution CT (HRCT) scores were compared. Results: The levels of HA, LN, C, IV and PC III in the experimental group were significantly lower than the control group(P<0.05); MMP-9, T1MP-1 level were significantly lower than the control group(P<0.05); β2-MG, mALB level were significantly lower than the control group(P<0.05); HRCT score were significantly lower than the control group(P<0.05). Conclusion: Cyclosporin combined with methylprednisolone sodium succinate can significantly reduce the index of serum fibrosis in patients with paraquat induced pulmonary fibrosis, alleviate the process of pulmonary fibrosis, reduce the level of urinary beta 2-MG and mALB, and reduce renal function damage.
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2018, Vol. 24 
