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| The Relationship between the Pathological Characteristics of Laryngeal Carcinoma and Angiogenesis and Effect on the Short-term Efficiency |
| GU Lei, WEN Fei, XIAO Jie |
| Huangshi Central Hospital of the Eastern Hubei Medical Group / Affiliated Hospital of Hubei Polytechnic University, Hubei Huangshi 435000, China |
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Abstract Objective: To analyze the correlation of pathological features of laryngeal cancer with the angiogenesis and its impact in the short-term clinical effective rate. Methods: 120 patients with laryngeal cancer treated from February 2016 to February 2017 in our hospital were selected. The correlation of pathological features of laryngeal cancer with the angiogenesis was analyzeds; the subjects were divided into positive group and negative group according to the VM (vasculogenic mimicry) results. The clinical effective rate for two groups was compared. Results: The MVD (microvessel density) for patients over 60 years old was significantly higher than patients below 60 years old; the MVD for glottic patients was significantly higher than supraglottic and subglottic patients;the MVD for male patients was significantly higher than female patients;the MVD for poorly differentiated patients was significantly higher than moderately and highly differentiated patients (P<0.05); the MVD for T3 and T4 of patients was higher than T1 and T2 of patients; the MVD for N1-3 group was higher than N0 patients; the MVD for stage Ⅲ and Ⅳ of patients was higher than stage Ⅰ and Ⅱ of patients (P＞0.05); there were 67 positive cases of VM and HIF-1α(hypoxia-inducible factor); the results indicated that the two indicators were closely correlated with each other (r=0.526, P<0.0 5); the short-term effective rate for VM positive cases was lower than negative cases (P<0.05). Conclusion: There is a significant correlation between pathological features such as age, sex and degree of differentiation with angiogenesis, and the prognosis of VM positive patients is often poor, which needs to be paid attention to by medical staff.
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[1] 冯彦,王斌全,梁钢,等.喉鳞状细胞癌组织中血管生成拟态与临床病理学特征关系的研究[J].临床耳鼻咽喉头颈外科杂志,2015,1(23):2071~2075.
[2] 瞿帅,宋杨,梅金玉,等.IL-17及其受体调控JAK/STAT3信号通路促进喉癌血管生成的作用[J].安徽医科大学学报,2015,50(10):1464~1467.
[3] 程卫.Nodal在喉癌组织中表达及临床意义[J].中华实用诊断与治疗杂志,2016,30(6):581~583.
[4] Gourin C G, Starmer H M, Herbert R J, et al. Short- and long-term outcomes of laryngeal cancer care in the elderly[J]. Laryngoscope, 2015, 125(4):924~933.
[5] 向军益,李圆,赵凯跃,等.喉癌CT灌注参数与血管内皮生长因子表达的相关性研究[J].中华全科医学,2016,14(3):445~448.
[6] 张春明,高伟,王斌全,等.喉鳞状细胞癌中的血小板反应蛋白-2的表达及与微血管生成的关系研究[J].中国药物与临床,2016,16(4):457~459.
[7] Been L B, Hoekstra H J, Suurmeijer A J H, et al. [F-18]FLT-PET and [F-18]FDG-PET in the evaluation of radiotherapy for laryngeal cancer[J]. Oral Oncology, 2015, 45(12):e211~215.
[8] Choe M H, Min J W, Jeon H B, et al. ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic marker for laryngeal cancer.[J]. Oncotarget, 2015, 6(5):2654~2666.
[9] 刘权忠,黄国鹏.血清水通道蛋白-1在喉癌中的表达及临床病理特征的关系[J].河北医学,2015,3(1):118~122. |
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2018, Vol. 24 
